An electronic nose in the discrimination of patients with asthma and controls

Dragonieri, Silvano; Schot, Robert; Mertens, Bart; Cessie, Saskia le; Gauw, Stefanie A.; Spanevello, Antonio; Resta, Onofrio; Willard, N. P.; Vink, T. J.; Rabe, Klaus F.; Bel, Elisabeth H.; Sterk, Peter J.

doi:10.1016/j.jaci.2007.05.043

Cited by 396 publications

(414 citation statements)

References 36 publications

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“…The CPA electronic nose is capable of picking up differences due to smoking status [22], but because training is specific for the VOC pattern profile relevant for a particular disease, irrelevant compounds are ignored. This implies that the effects of smoking are unlikely to have a significant confounding effect, as has been found in other studies in lung cancer and also in obstructive lung disease [15,35,36].…”

Section: Discussionsupporting

confidence: 68%

“…Significant differences in resistance are then selected by PCA. Hence, smell print pattern recognition by CPA electronic noses is purely based on a statistical approach, providing empiric evidence [36]. However, studies are underway to identify individual breath components and it is likely that these will be characterised in the near future.…”

Section: Discussionmentioning

confidence: 99%

“…VOCs are produced both from endogenous and exogenous processes, so there is also a possibility of background environmental contamination. We did not use a VOC filter, but this is likely to improve accuracy [15,36,38]. However, our patients were all studied in an identical air conditioned environment typical of usual clinical practice, and there are few published data regarding optimal filter type or methods in this area.…”

Section: Discussionmentioning

confidence: 99%

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A breath test for malignant mesothelioma using an electronic nose

et al. 2011

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Malignant mesothelioma (MM) is a rare tumour which is difficult to diagnose in its early stages. Earlier detection of MM could potentially improve survival. Exhaled breath sampling of volatile organic compounds (VOCs) using a carbon polymer array (CPA) electronic nose recognises specific breath profiles characteristic of different diseases, and can distinguish between patients with lung cancer and controls. With MM, the potential confounding effect of other asbestos-related diseases (ARDs) needs to be considered. We hypothesised that as CPA electronic nose would distinguish patients with MM, patients with benign ARDs, and controls with high sensitivity and specificity.20 MM, 18 ARD and 42 control subjects participated in a cross-sectional, case-control study. Breath samples were analysed using the Cyranose 320 (Smiths Detection, Pasadena, CA, USA), using canonical discriminant analysis and principal component reduction.10 MM subjects created the training set. Smell prints from 10 new MM patients were distinguished from control subjects with an accuracy of 95%. Patients with MM, ARDs and control subjects were correctly identified in 88% of cases.Exhaled breath VOC profiling can accurately distinguish between patients with MM, ARDs and controls using a CPA electronic nose. This could eventually translate into a screening tool for high-risk populations.

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Section: Discussionsupporting

confidence: 68%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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A breath test for malignant mesothelioma using an electronic nose

et al. 2011

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“…Electronic noses have been applied to various analysis fields such as food [33,34] and various diseases; diabetes [35], uremia [36], asthma [37], chronic obstructive pulmonary disease [38], pulmonary sarcoidosis [39], colorectal cancer [40], and malignant mesothelioma [41,42]. The application of electronic noses to detect lung cancer was also proposed.…”

Section: Discussionmentioning

confidence: 99%

Analysis of volatile organic compounds in exhaled breath for lung cancer diagnosis using a sensor system

Chang

Lee

Ban

et al. 2018

Sensors and Actuators B: Chemical

122

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“…Analysis of VOCs in exhaled breath consisted of three principal steps; namely, the adsorption of VOCs on to sorbent cartridges, thermal desorption and analysis by GC-MS 11,17 . The sorbent cartridge was composed of a cylindrical stainless steel net (100 mesh) with an external diameter of 4·8 mm containing Carboxen TM 1003, Carbopack TM B and Carbopack TM Y as an adsorbent bed (Sigma Aldrich, Milan, Italy).…”

Section: Analysis Of Volatile Organic Compoundsmentioning

confidence: 99%

Exhaled volatile organic compounds identify patients with colorectal cancer (Br J Surg 2013; 100: 144–150)

Zbar

2012

British Journal of Surgery

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Background: An effective screening tool for colorectal cancer is still lacking. Analysis of the volatile organic compounds (VOCs) linked to cancer is a new frontier in cancer screening, as tumour growth involves several metabolic changes leading to the production of specific compounds that can be detected in exhaled breath. This study investigated whether patients with colorectal cancer have a specific VOC pattern compared with the healthy population.Methods: Exhaled breath was collected in an inert bag (Tedlar  ) from patients with colorectal cancer and healthy controls (negative at colonoscopy), and processed offline by thermal-desorber gas chromatography-mass spectrometry to evaluate the VOC profile. During the trial phase VOCs of interest were identified and selected, and VOC patterns able to discriminate patients from controls were set up; in the validation phase their discriminant performance was tested on blinded samples. A probabilistic neural network (PNN) validated by the leave-one-out method was used to identify the pattern of VOCs that better discriminated between the two groups.

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An electronic nose in the discrimination of patients with asthma and controls

Cited by 396 publications

References 36 publications

A breath test for malignant mesothelioma using an electronic nose

A breath test for malignant mesothelioma using an electronic nose

Analysis of volatile organic compounds in exhaled breath for lung cancer diagnosis using a sensor system

Exhaled volatile organic compounds identify patients with colorectal cancer (Br J Surg 2013; 100: 144–150)

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