An electron microscopic study on substance P-like immunoreactive nerve fibers in the pars distalis of the adenohypophysis in the dog

Ju, Gong; Zhang, X.

doi:10.1016/0306-4522(90)90046-7

Cited by 30 publications

(25 citation statements)

References 33 publications

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“…A few SP-and CGRP-LI nerve fibers have also been identified in the rat in other laboratories [12][13][14][15]. Confirming their presence in the rat, we found them to be much more abundant than what had been reported [16], Moreover, we were able to demon strate synaptic contacts between the SP-or CGRP-LI nerve fibers and the corticotropes and somatotropes in the dog [17,18], Synapses have also been found by us in Prof. Gong Ju …”

supporting

confidence: 70%

Response of Calcitonin-Gene-Related Peptide-Like Immunoreactive Nerve Fibers of the Anterior Pituitary to Adrenalectomy in the Rat

Ju¹,

Ma²,

Fan

1994

Neuroendocrinology

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The mammalian anterior pituitary is known to be regulated by humoral factors only, no direct neural influence having ever been discovered. Our recent studies have shown in several species that there are substantial amounts of substance P and calcitonin-gene-related peptide-like immunoreactive (CGRP-LI) nerve fibers in the anterior pituitary and that they can make synaptic contacts with secretory cells, among which corticotropes. In the present study, we investigated changes in CGRP-LI nerve fibers of the anterior pituitary after bilateral adrenalectomy in the rat. The results show that the number of CGRP-LI nerve fibers increases significantly. In parallel, they cover a wider area of the gland after the operation, suggesting a direct neural influence.

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supporting

confidence: 70%

Response of Calcitonin-Gene-Related Peptide-Like Immunoreactive Nerve Fibers of the Anterior Pituitary to Adrenalectomy in the Rat

Ju¹,

Ma²,

Fan

1994

Neuroendocrinology

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“…They were mainly distributed among the gland cells and in close relationship to the gland cells rather than to the blood vessels (Ju & Liu 1989e,c). Of pivotal importance are our discoveries of synaptic contacts with the gland cells in the anterior pituitary of the dog 0u & Zhang 1990& Zhang , 1992; this has demonstrated the motor nature of the nerve fibers and strongly suggests a direct neural regulation of the anterior pituitary. This has been further confirmed by the response of the nerve fibers to hormone manipulations.…”

Section: Discussionmentioning

confidence: 98%

“…It has been reported in our previous studies and also by other laboratories that there are peptidergic nerve fibers in the anterior pituitary of several mammalian species, including the rat (Rosenfeld et al 1983, Westlund et al 1983, Skofitsch & Jacobowitz 1985, Tschopp et al 1985, Liu &Ju 1988, Mikkelsen et al 1989, Gon et al 1990, Ju & Liu 1989a, Ju & Zhang 1990, Ju et al 1991. They have been found to be in close contact with the gland cells (Ju & Liu 19896,c), even to make synaptic contacts with them (Ju & Zhang 1990. Furthermore, Ju et al (1994) found that 4 days after adrenalectomy an increase in the number of calcitonin gene-related peptide (CGRP)-like immuno¬ reactive (LI) nerve fibers in the anterior pituitary was induced.…”

Section: Introductionmentioning

confidence: 94%

Evidence for axonal sprouting in the anterior pituitary following adrenalectomy in the rat

Meng²,

Benowitz³

et al. 1995

Journal of Endocrinology

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Our recent studies have demonstrated the presence of peptidergic nerve fibers in the anterior pituitary of the rat. They were found to increase in number following adrenalectomy and the present study was aimed at investigating whether axonal sprouting could account for this increase. Antibody against the neuronal growth-associated protein GAP-43 was used as the probe. Four days following adrenalectomy GAP-43-like immunoreactivity was found to increase dramatically, mostly as varicosities surrounding the gland cells. The results suggest an active axonal sprouting following this hormone manipulation and strongly support our hypothesis of neural-humoral dual regulation of the mammalian anterior pituitary.

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“…In addition, SP-positive immunoreactive nerve fibers have been identified in the anterior pituitary of monkeys (Ju and Liu, 1989), dogs (Ju and Liu, 1990;Ju and Zhang, 1990), rats (Larsen, 1992;Ju and Liu, 1993), and humans (Liu, 2004), in close contact with secretory cells. The latter observation has led researchers to believe that neurokinins may also act directly on the pituitary gland via a neurologic mechanism, as well as by influencing hypothalamic-releasing hormones.…”

Section: Discussionmentioning

confidence: 99%

Administration of an Antagonist of Neurokinin Receptors 1, 2, and 3 Results in Reproductive Tract Changes in Beagle Dogs, but Not Rats

Losco¹,

Leach²,

Sinha³

et al. 2007

Toxicol Pathol

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SCH 206272, an antagonist of neurokinin receptors 1, 2, and 3, was administered orally by gavage for 1 month to 8-to 10-month-old dogs at doses of 0, 15, 30, or 60 mg/kg, and to 6-week-old rats at doses of 0, 30, 100, or 300 mg/kg. The most important changes occurred in the reproductive tract of the dogs at all doses. Absolute and relative group mean organ weights for the testes, prostate gland, epididymides, ovaries, and uterus were 33-86% lower than concurrent controls in groups receiving SCH 206272. Organ weight changes were not dose-related. Microscopic changes that correlated with the organ weight changes occurred in all groups receiving SCH 206272. For males, they included minimal to severe atrophy of the testes, epididymides, and prostate gland. In addition, the epididymides exhibited severe oligospermia or aspermia, minimal epithelial apoptosis and mild epithelial vacuolation. In female dogs, the ovaries and uteri appeared immature. Microscopic changes were similar in incidence and severity in dogs receiving 30 or 60 mg/kg, but were slightly less in dogs receiving 15 mg/kg. In contrast, similar findings were not observed in the reproductive tract of male or female rats, despite overlapping systemic, hypothalamic, and pituitary gland concentrations of SCH 206272.

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An electron microscopic study on substance P-like immunoreactive nerve fibers in the pars distalis of the adenohypophysis in the dog

Cited by 30 publications

References 33 publications

Response of Calcitonin-Gene-Related Peptide-Like Immunoreactive Nerve Fibers of the Anterior Pituitary to Adrenalectomy in the Rat

Response of Calcitonin-Gene-Related Peptide-Like Immunoreactive Nerve Fibers of the Anterior Pituitary to Adrenalectomy in the Rat

Evidence for axonal sprouting in the anterior pituitary following adrenalectomy in the rat

Administration of an Antagonist of Neurokinin Receptors 1, 2, and 3 Results in Reproductive Tract Changes in Beagle Dogs, but Not Rats

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