An electron‐microscope study of defibrination during carbon clearance in rabbits stimulated by a tubercle bacillary lipid

Ultrastructural changes in the microvasculature following cryosurgery of oral mucosa

“…The membrane bounded granular bodies seen in the lomen of both capillaries and venules after freezing are considered to be extravasated cell nuclei (Donald 1972). The presence of platelets in vessels damaged by freezing is important in view of their role in the initiation of vessel stasis.…”

Disseminated intravascular coagulation: a review.

“…These 'haematoxylinophil bodies' circulate, and can be numerous, and occasionally aggregated and compacted, in pulmonary capillaries. Their association with fibrin-like material in microvessels has been suggested as presumptive evidence of DIC (Simpson et al, 1971); experimental (Donald, 1972) and clinicopathological (Goodall, 1973) support exists for this view, although it has not yet been fully tested. Goodall has also pointed to the value of examining the buffy coat of the blood for irregular nuclear masses as a ready way of drawing attention to the diagnosis of DIC in the living.…”

Fibrin deposition in pregnancy

“…These have been shown to be extruded nuclei of endothelial cells; they tend to aggregate in the lung where they form irregular nuclear masses; if associated with granular material in the microvasculature they may provide a useful pointer to an episode of recent intravascular coagulation (Simpson et al, 1971;Donald, 1972;Goodall, 1973). There is current interest in the possibility that swelling and blebbing of endothelial cell cytoplasm, culminating in nuclear loss, might represent a response by the endothelial cell that is releasing plasminogen activator in relation to adjacent deposition of fibrin.…”