An Electromagnetic Microvalve for Pneumatic Control of Microfluidic Systems

Liu, Xuling; Li, Songjing

doi:10.1177/2211068214531760

Cited by 27 publications

(16 citation statements)

References 26 publications

(27 reference statements)

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“…As illustrated in Figure 7a and b, the microvalve was connected to a screw at the bottom of the electromagnetic actuator; this enables the valve-opening degree to be adjustable. 30 The exact valve head position could be determined via the micrometer M3*30 screw (GB818-85). The inlet of the microvalve was connected to a gas supply, the outlet tube was connected to a port of the flow sensor (ASF1430, SENSIRION Company, Switzerland), and another port of the flow sensor was connected to the atmosphere.…”

Section: Hydraulic Resistancementioning

confidence: 99%

Numerical Simulation on the Response Characteristics of a Pneumatic Microactuator for Microfluidic Chips

Liu

Bao

2016

SLAS Technology

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This article presents a multiphysical system modeling and simulation of a pneumatic microactuator, which significantly influences the performance of a particular pneumatic microfluidic device. First, the multiphysical system modeling is performed by developing a physical model for each of its three integrated components: microchannel with a microvalve, a gas chamber, and an elastomer membrane. This is done for each step of operation for the whole system. The whole system is then considered a throttle blind capacitor model, and it is used to predict the response time of the pneumatic microactuator by correlating its characteristics such as gas pressurizing, hydraulic resistance, and membrane deformation. For this microactuator, when the maximum membrane deformation is 100 µm, the required actuated air pressure is 80 kPa, and the response time is 1.67 ms when the valve-opening degree is 0.8. The response time is 1.61 ms under fully open conditions. These simulated results are validated by the experimental results of the current and previous work. A correlation between the simulated and experimental results confirms that the multiphysical modeling presented in this work is applicable in developing a proper design of a pneumatic microactuator. Finally, the influencing factors of the response time are discussed and analyzed.

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Section: Hydraulic Resistancementioning

confidence: 99%

Numerical Simulation on the Response Characteristics of a Pneumatic Microactuator for Microfluidic Chips

Liu

Bao

2016

SLAS Technology

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“…Manual sequential delivery of reagents for multi-step processes on conventional laboratory platforms, such as slides or 96-well plates, is a time-consuming and laborintensive task. Off-chip switching can be performed using multiple-position selection valves, 12 solenoid valves, 13 electromagnetic valves, 14 or pressure controllers, 15 and benefits from the relatively high reliability of these instruments, while maintaining simple fabrication of the microfluidic layer as it does not need to include on-chip moving parts. via pipetting robots) has enabled the wide-spread use of such assays, particularly in clinical laboratories, where high throughput is required.…”

Section: Introductionmentioning

confidence: 99%

Delivery of minimally dispersed liquid interfaces for sequential surface chemistry

2016

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We present a method for sequential delivery of reagents to a reaction site with minimal dispersion of their interfaces. Using segmented flow to encapsulate the reagents as droplets, the dispersion between reagent plugs remains confined in a limited volume, while being transmitted to the reaction surface. In close proximity to the target surface, we use a passive array of microstructures for removal of the oil phase such that the original reagent sequence is reconstructed, and only the aqueous phase reaches the reaction surface. We provide a detailed analysis of the conditions under which the method can be applied and demonstrate maintaining a transition time of 560 ms between reagents transported to a reaction site over a distance of 60 cm. We implemented the method using a vertical microfluidic probe on an open surface, allowing contact-free interaction with biological samples, and demonstrated two examples of assays implemented using the method: measurements of receptor-ligand reaction kinetics and of the fluorescence response of immobilized GFP to local variations in pH. We believe that the method can be useful for studying the dynamic response of cells and proteins to various stimuli, as well as for highly automated multi-step assays.

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“…Detailed information about the fabrication process can be found in our previous studies. 24,25 The measured sizes of the mixing chamber and actuated chamber are 1.0 × 1.0 × 0.1 mm and 0.8 × 0.8 × 0.1 mm, respectively, as shown in Figure 2 . The center positions of the mixing chamber and actuated chamber overlap, forming a symmetrical structure.…”

Section: Methodsmentioning

confidence: 98%

RGB Color Model Analysis for a Simple Structured Polydimethylsiloxane Pneumatic Micromixer

et al. 2021

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An Electromagnetic Microvalve for Pneumatic Control of Microfluidic Systems

Cited by 27 publications

References 26 publications

Numerical Simulation on the Response Characteristics of a Pneumatic Microactuator for Microfluidic Chips

Numerical Simulation on the Response Characteristics of a Pneumatic Microactuator for Microfluidic Chips

Delivery of minimally dispersed liquid interfaces for sequential surface chemistry

RGB Color Model Analysis for a Simple Structured Polydimethylsiloxane Pneumatic Micromixer

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