1986
DOI: 10.1007/bf01620551
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An electroencephalographic processing algorithm specifically intended for analysis of cerebral electrical activity

Abstract: This article describes a computer procedure for the examination and analysis of cerebral electrical activity (CEA). Changes in CEA generate random electrical activity and may include transitory events, such as burst episodes. As yet, there are no standard techniques for evaluating the statistical process of the CEA. This article proposes a computerized method of analyzing the stochastic character of CEA using a computer algorithm. Using a real-time wave-by-wave technique, the algorithm characterizes CEA by the… Show more

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Cited by 63 publications
(14 citation statements)
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“…Briefly, the electrodes were placed at the locations 11 mm anterior and + 2.5 mm lateral (FI and F) (Gregory & Pettus, 1986 (Rathburn) in a ratio 50/50 with a flow rate of 1.0mlmin-. Retention times were 4.4 and 5.0 min for diazepam and midazolam respectively.…”
Section: Pharmacokinetic-pharmacodynamic Experimentsmentioning
confidence: 99%
See 1 more Smart Citation
“…Briefly, the electrodes were placed at the locations 11 mm anterior and + 2.5 mm lateral (FI and F) (Gregory & Pettus, 1986 (Rathburn) in a ratio 50/50 with a flow rate of 1.0mlmin-. Retention times were 4.4 and 5.0 min for diazepam and midazolam respectively.…”
Section: Pharmacokinetic-pharmacodynamic Experimentsmentioning
confidence: 99%
“…Two EEG leads (F,-C, and C-Oi) were subjected to on-line aperiodic analysis for quantification, using the Lifescan EEG monitor (Neurometrics Inc., San Diego, U.S.A.). Aperiodic analysis was recently introduced as a new technique to quantify brain electrical activity (Gregory & Pettus, 1986). The aperiodic analysis algorithm calculates the amplitude and period of each EEG signal on a wave by wave basis.…”
Section: Pharmacokinetic-pharmacodynamic Experimentsmentioning
confidence: 99%
“…In a series of studies, aimed at the development of a pharmacokinetic-pharmacodynamic drug-drug interaction model for flumazenil and midazolam, we first determined the pharmacokinetics and pharmacodynamics of midazolam (Breimer et al 1990). In that study, the total number of waves in the 12-30Hz frequency range (TNW 12-30), a parameter derived from the EEG with aperiodic analysis (Gregory & Pettus 1986), was used to quantify the effect of midazolam. In the second study we investigated the effect of flumazenil on TNW [12][13][14][15][16][17][18][19][20][21][22][23][24][25][26][27][28][29][30] and determined the pharmacokinetics of this drug (Breimer et al 1989a), demonstrating that flumazenil has no intrinsic effect on TNW 12-30 (Breimer et al 1989b).…”
mentioning
confidence: 99%
“…By applying aperiodic analysis (Gregory & Pettus, 1986) the total amplitude in the frequency area of 11.5 to 30 Hz of the fronto-central EEG lead was calculated and used as the descriptor of the drug effect, because this was shown to provide an optimal measure for the effect of midazolam on the central nervous system (Mandema et al, 1991b). More detailed information on the recording and analysis of the EEG are described by Mandema et al (1991a).…”
Section: W11" Macmillan Pressmentioning
confidence: 99%