An Electrochemical Sensor Based On Graphite Electrode Modified With Silica Containing 1-N-Propyl-3-Methylimidazolium Species For Determination Of Ascorbic Acid

Abstract

In the present study, an electrochemical sensor based on the electrode (SiMImCl/C) consisting of graphite and silica, grafted with 1-n-propyl-3-methylimidazolium chloride was used for ascorbic acid (AA) quantification in pharmaceuticals and food formulations. Cyclic voltammetry and electrochemical impedance spectroscopy were applied for electrochemical characterization of the SiMImCl/C electrode. The cyclic voltammetry study revealed that the oxidation of AA on this electrode is an irreversible process, realized by adsorption and diffusion limited step. The differential pulse voltammetry was applied to develop a procedure for the AA determination. The linear range was found to be 0.3–170 μmol L-1 and the limit of detection – 0.1 μmol L-1. The proposed SiMImCl/C electrode has long term stability and does not show electrochemical activity towards the analytes, which commonly coexist with AA. The sensor was successfully used for quantification of AA in food and pharmaceutical formulations.

Selective Voltammetric Detection of Ascorbic Acid from Rosa Canina on a Modified Graphene Oxide Paste Electrode by a Manganese(II) Complex

“…The relative standard deviation was measured at two levels of concentration mass of AA, i.e., 45 μg L −1 and 158 μg L −1 and calculated to be 4.2 % and 3.8%, respectively, values indicating the good reproducibility of the proposed assay. The linear detection region of AA in the present study is in several cases better than that determined by the corresponding electrochemical techniques in the literature [ 11 , 12 , 13 , 14 , 15 , 16 , 17 , 18 , 19 , 20 , 21 , 22 , 23 , 24 , 25 , 26 , 27 , 28 , 29 , 30 , 31 , 32 , 33 , 34 , 35 , 36 , 37 , 38 , 39 , 40 , 41 , 45 ] On the other hand, the detection limit of the current analytical AA detection methodology is better compared to the majority of those determined with the other corresponding electrochemical techniques available in the literature, with the exception that it is in the same magnitude of Zhao et 2019 [ 20 ], Kaçar and Erden 2020 [ 2 ], Broncová et al 2021 [ 34 ], Pekin et al [ 45 ], as it can be seen from Table 1 .…”

“…However, some of these techniques are time-consuming; some are poor in sensitivity and selectivity, while others are costly or need specially trained operators. On the other hand, electrochemical techniques offer the advantages of the low cost of buying and operating the instruments, the high sensitivity, and the simplicity of the method [ 11 , 12 , 13 , 14 , 15 ]. Furthermore, electroanalytical methods are reproducible, have relatively short analysis time and can be used in the direct analysis, without any extraction, clean-up or pre-concentration steps, and are easy to miniaturize and handle [ 11 , 12 , 13 , 14 , 15 ].…”

Low Overpotential Amperometric Sensor using Yb2O3.CuO@rGO Nanocomposite for Sensitive Detection of Ascorbic Acid in Real Samples

“…It is essential to numerous bodily metabolic activities including activating the immune system, aiding in wound healing, helping with the absorption of iron, and protecting against damage to bones and teeth [2]. Additionally, AA serves as a cofactor during the synthesis of collagen and carnitine [3]. In addition, AA has been demonstrated to provide protective effects against oxidative illnesses like heart disease, several cancers, AIDS, the common cold, etc.…”

Low Overpotential Amperometric Sensor Using Yb2O3.CuO@rGO Nanocomposite for Sensitive Detection of Ascorbic Acid in Real Samples

“…It is essential to numerous bodily metabolic activities including activating the immune system, aiding in wound healing, helping with the absorption of iron, and protecting against damage to bones and teeth [ 2 ]. Additionally, AA serves as a cofactor during the synthesis of collagen and carnitine [ 3 ]. In addition, AA has been demonstrated to provide protective effects against oxidative illnesses such as heart disease, several cancers, AIDS, the common cold, etc.…”