An electrochemical sensor based on poly(procaterol hydrochloride)/carboxyl multi-walled carbon nanotube for the determination of bromhexine hydrochloride

Kong, Dexian; Han, Libin; Wang, Zeming; Jiang, Lili; Zhang, Qian; Wu, Qiong; Su, Jing; Lü, Chunhua

doi:10.1039/c8ra08510b

Cited by 3 publications

(3 citation statements)

References 38 publications

(42 reference statements)

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“…Here, we have considered the Pd (111) diffraction From the EIS it was found that CNT-Pd (SBH) shows the lowest Rs and Rct values which can be attributed to the excellent electron efficiency of CNT-Pd (SBH) electrode. 24,25 From the above discussion, it is clear that the CNT-Pd (SBH) modified electrode was highly conductive with excellent catalytic activity at the interface compared to the other mentioned electrodes.…”

Section: Resultsmentioning

confidence: 96%

The Effect of Reducing Agent for Synthesizing Palladium Nanoparticle on Carbon Nanotube Support and Its Superior Catalytic Activity towards Methanol Oxidation Reaction

et al. 2023

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We have synthesized carbon nanotube supported palladium nanoparticles (CNT-Pd) by using different reducing agents such as sodium borohydride (SBH), hydrazine monohydrate (HY), and ascorbic acid (AA) for the methanol oxidation reaction (MOR) in alkaline media. The elemental and morphological properties of all catalysts are verified by high-resolution transmission electron microscopy (HRTEM), X-ray photoelectron spectroscopy, and X-ray diffraction. From the HRTEM images, it is found that CNT-Pd reduced by sodium borohydride CNT-Pd (SBH) exhibited a narrow size distribution of Pd nanoparticles (PdNPs) with an average size of 3.15 nm. The role of the reducing agents (SBH, HY, and AA) is investigated by applying them as anode catalysts for the methanol oxidation reaction (MOR) and it is found that the reducing agent remarkably affected the electrochemical activities. CNT-Pd (SBH) catalysts show the superior catalytic activity and durability towards MOR among all catalysts, which may be due to the Pd NPs in CNT-Pd (SBH) having a perfect crystal structure with a narrow size distribution.

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Section: Resultsmentioning

confidence: 96%

The Effect of Reducing Agent for Synthesizing Palladium Nanoparticle on Carbon Nanotube Support and Its Superior Catalytic Activity towards Methanol Oxidation Reaction

et al. 2023

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“…Many methods have been reported for the estimation of BHH in its pure form or pharmaceutical preparations. These methods include spectrophotometry [12][13][14], chromatography [15][16][17][18], voltammetry [19,20] and capillary electrophoresis [21]. However , spectrophotometric methods are still more spread than other techniques due to their simplicity and inexpensive equipment.…”

Section: Figure 1-bromhexine Hydrochloridementioning

confidence: 99%

Spectrophotometric Determination of Bromhexine Hydrochloride by Diazotization and Coupling Method in Its Pharmaceutical Preparations

Sultan

Majed

2020

eijs

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A simple, fast, and sensitive spectrophotometric method was suggested for the determination of Bromhexine Hydrochloride (BHH) in its pharmaceutical formulations. The method depends on the diazotization of BHH by sodium nitrite in acidic medium to produce the corresponding diazonium salt. The latter is coupled with phloroglucinol reagent in alkali medium to form a yellow water soluble azo-dye which has a maximum absorption at 405 nm with a molar absorptivity of 2.7×104 l.mol-1.cm-1 and Sandellʼs sensitivity of 0.01517 µg.cm-1. Beerʼs low is obeyed within a concentration range of 0.25-15 µg.mL-1 of BHH. The LOD and LOQ values of the proposed method were 0.087 µg.mL-1 and 0.293 µg.ml-1, respectively. The proposed method was validated with standard methods and successfully applied to the determination of Bromhexine in its pharmaceutical formulations as tablets, syrup, and injections.

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“…Moreover, high doses of BHC can cause nausea, rash, diarrhea, and other adverse effects. Thus, the accurate quantification of BHC in pharmaceutical products and clinical samples is critical [4]. Several analytical techniques have been employed for BHC analysis, including high-performance liquid chromatography (HPLC) [5], spectrophotometry [6], electrochemiluminescence [7], and potentiometric titration [8].…”

Section: Introductionmentioning

confidence: 99%

Electrodeposition of Cobalt Oxides on Carbon Nanotubes for Sensitive Bromhexine Sensing

et al. 2022

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We develop an electrochemical sensor for the determination of bromhexine hydrochloride (BHC), a widely use mucolytic drug. The sensor is prepared by electrodeposition of cobalt oxides (CoOx) on a glassy carbon electrode modified with carboxylated single-walled carbon nanotubes (SWCNT). A synergistic effect between CoOx and SWCNT is observed, leading to a significant improvement in the BHC electrooxidation current. Based on cyclic voltammetry studies at varying scan rates, we conclude that the electrochemical oxidation of BHC is under mixed diffusion–adsorption control. The proposed sensor allows the amperometric determination of BHC in a linear range of 10–500 µM with a low applied voltage of 0.75 V. The designed sensor provides reproducible measurements, is not affected by common interfering substances, and shows excellent performance for the analysis of BHC in pharmaceutical preparations.

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An electrochemical sensor based on poly(procaterol hydrochloride)/carboxyl multi-walled carbon nanotube for the determination of bromhexine hydrochloride

Abstract: The fabrication process of the p-ProH/CMWCNT/GCE.

Cited by 3 publications

References 38 publications

The Effect of Reducing Agent for Synthesizing Palladium Nanoparticle on Carbon Nanotube Support and Its Superior Catalytic Activity towards Methanol Oxidation Reaction

The Effect of Reducing Agent for Synthesizing Palladium Nanoparticle on Carbon Nanotube Support and Its Superior Catalytic Activity towards Methanol Oxidation Reaction

Spectrophotometric Determination of Bromhexine Hydrochloride by Diazotization and Coupling Method in Its Pharmaceutical Preparations

Electrodeposition of Cobalt Oxides on Carbon Nanotubes for Sensitive Bromhexine Sensing

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