An electrochemical method for measurement of mass transport in polymer membranes using acetaminophen as a model system

Rong, Zimei; Vadgama, Pankaj

doi:10.1016/j.electacta.2009.03.091

Cited by 6 publications

(7 citation statements)

References 19 publications

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“…Electrode current response was then monitored from baseline to maximum, steady state, values. Formal diffusion coefficients were obtained from the electrode response profiles using a previously reported computational model . In brief, this employed curve fitting software to match experimental curves.…”

Section: Methodsmentioning

confidence: 99%

“…Formal diffusion coefficients were obtained from the electrode response profiles using a previously reported computational model. [19] In brief, this employed curve fitting software to match experimental curves. The model was derived from two separate equations for the complete response, which operated, respectively, over the early and late time domains.…”

Section: Oxygen Diffusivitymentioning

confidence: 99%

See 1 more Smart Citation

Enhanced hydration stability of Bombyx mori silk fibroin/PEG 600 composite scaffolds for tissue engineering

Selmin

Gennari

Minghetti

et al. 2014

Polymers for Advanced Techs

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Silk fibroin scaffolds obtained via regeneration by Ajisawa's reagent (CaCl2/H2O/EtOH, mole ratio 1:8:2) and freeze‐drying followed by steam sterilization resulted unstable when incubated in physiological medium over 1‐month period since the oxygen diffusivity and mechanical resistance to compression significantly decreased. Blending of regenerated silk fibroin with PEG 600 lead to a novel scaffold with an improved water stability. Multi‐parameter characterization has revealed that scaffolds made by composite material were stable in physiological media over at least 1 month of incubation. Interestingly, the presence of PEG has a notable impact on wettability and protein adsorption. This increase in hydrophilicity could be beneficial for initial cell adhesion and survival as well as for the adsorptive loading of growth factors. Copyright © 2014 John Wiley & Sons, Ltd.

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Section: Methodsmentioning

confidence: 99%

Section: Oxygen Diffusivitymentioning

confidence: 99%

Enhanced hydration stability of Bombyx mori silk fibroin/PEG 600 composite scaffolds for tissue engineering

Selmin

Gennari

Minghetti

et al. 2014

Polymers for Advanced Techs

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“…If these materials are to be introduced as biosensor materials more widely [ 34 ] further insight into ageing effects are warranted. We combined cyclic voltammetric [ 35 ] and chronoamperometric [ 36 , 37 ] measurements of simple probe molecules for non-destructive tracking of permeability changes (bulk property) and later correlated this with destructive mechanical testing of adhesion (surface property) at bone surfaces.…”

Section: Introductionmentioning

confidence: 99%

“…With this latter approach we monitored and matched responses on a real time basis against model simulated responses incorporating Fick's Laws. We have previously reported on software to achieve this based on a bipartite, time partitioned, solution to Fick's Laws that combines speed, repeatability and simplicity [ 37 , [44] , [45] , [46] , [47] , [48] , [49] ].…”

Section: Introductionmentioning

confidence: 99%

An electrochemical study of acrylate bone adhesive permeability and selectivity change during in vitro ageing: A model approach to the study of biomaterials and membrane barriers

Raja

Shelton

Salamat-Zadeh

et al. 2019

Analytica Chimica Acta: X

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This study assessed the solute permeability of a family of UV and moisture cured acrylates-based adhesives during in vitro ageing in pH 7.4 buffer. Acrylates have a potential role in bone fracture fixation, but their inability to allow microsolute exchange between the fractured bone surfaces may contribute to ineffective healing. Cyclic voltammetry and chronoamperometry were used to determine the diffusion coefficients for various electrochemically active probe molecules (O 2, H 2 O 2 , acetaminophen, catechol, uric acid and ascorbic acid) at proprietary acrylic, urethane – acrylate and cyanoacrylate adhesives. All adhesives proved to be impermeable for up to 9 days ageing, following which a near-exponential increase in permeability resulted for all solutes. At 18 days, the diffusion coefficients were in the range of 10 −5 cm 2 s −1 for O 2 and H 2 O 2 and 10 −6 cm 2 s −1 for the organic solutes; no transport selectivity was seen between the latter. Adhesive joint strength showed a direct, inverse, correlation with permeability, with the more hydrophilic cyanoacrylates showing the greatest loss of strength. Adhesive permeabilisation does not appear to be compatible with the retention of bonding strength, but it serves as a new non-destructive predictor of adhesion strength change during ageing and practical use.

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“…18 In an important study, Tan and Tam have reported the application of a potentiometric drug selective electrode to monitor real-time drug (procaine hydrochloride) release from pH-responsive microgels. [24][25][26][27] In a previous paper, a bare glassy carbon electrode (GCE) was applied for the real-time electrochemical monitoring of doxorubicin release from a nanoparticle-based carrier. [20][21][22][23] More importantly, the electrochemical method is convenient for making decisions by obtaining real-time drug monitoring data.…”

mentioning

confidence: 99%

4-Phosphatephenyl-modified glassy carbon electrode for real-time and simultaneous electrochemical monitoring of paracetamol and diclofenac release from electrospun nanofibers

Zhou

Wang

et al. 2015

Anal. Methods

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An effective electrochemical platform was set up for the real-time and simultaneous monitoring of the kinetics of drug release from electrospun nanofibers. The method describes the development and utilization of a 4-phosphatephenyl (4-PP)-modified glassy carbon electrode (GCE). The modified electrode was used to monitor paracetamol (PCT) and/or diclofenac (DCF) release from electrospun nanofibers. The drug-loaded nanofibers were characterized by scanning electron microscopy (SEM) and Fourier transform infrared spectroscopy (FTIR). Using differential pulse voltammetry (DPV), the modified electrode shows good sensitivity and selectivity for the simultaneous determination of PCT (1.87 mM to 170 mΜ) and DCF (0.37s-51.87 mM). The release kinetics study reveals that the drug follows first order kinetics and that the mechanism of drug release was a diffusion-controlled type. No significant drugpolymer interactions were observed in the FTIR studies. The results obtained are promising, which demonstrates that the electrochemical method possesses the capability for the simultaneous detection of multiple molecules in a drug delivery system (DDS).

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An electrochemical method for measurement of mass transport in polymer membranes using acetaminophen as a model system

Cited by 6 publications

References 19 publications

Enhanced hydration stability of Bombyx mori silk fibroin/PEG 600 composite scaffolds for tissue engineering

Enhanced hydration stability of Bombyx mori silk fibroin/PEG 600 composite scaffolds for tissue engineering

An electrochemical study of acrylate bone adhesive permeability and selectivity change during in vitro ageing: A model approach to the study of biomaterials and membrane barriers

4-Phosphatephenyl-modified glassy carbon electrode for real-time and simultaneous electrochemical monitoring of paracetamol and diclofenac release from electrospun nanofibers

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