An electrochemical dopamine aptasensor incorporating silver nanoparticle, functionalized carbon nanotubes and graphene oxide for signal amplification

Bahrami, Shokoh; Abbasi, Amir Reza; Roushani, Mahmoud; Derikvand, Zohreh; Azadbakht, Azadeh

doi:10.1016/j.talanta.2016.05.060

Cited by 57 publications

(19 citation statements)

References 43 publications

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“…However, from another point of view, gold is a noble metal, and thus it is more expensive than most available materials. One alternative to overcome this drawback is found in research involving new electrode materials, such as carbon‐based electrodes, magnetic materials, and nanoparticles . Another trend focuses on the development of microelectrodes in miniaturized systems, which can reduce the manufacturing cost.…”

Section: Aptamer‐based Electrochemical Biosensorsmentioning

confidence: 99%

“…One alternative to overcome this drawback is found in research involving new electrode materials, such as carbon-based electrodes, [81] magnetic materials [82] , and nanoparticles. [83] Another trend focuses on the development of microelectrodes in miniaturized systems, which can reduce the manufacturing cost. In such cases, the latest trends show the use of interdigitated microelectrodes (IDE), [84] screen-printed electrodes (SPE) [85] and field-effect transistors (FETs).…”

Section: Aptamer-based Electrochemical Biosensorsmentioning

confidence: 99%

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Electrochemical Biosensors in Point‐of‐Care Devices: Recent Advances and Future Trends

et al. 2017

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The use of biosensors in point‐of‐care (POC) testing devices has attracted considerable attention in the past few years, mainly because of their high specificity, portability, and relatively low cost. Coupling these devices with miniaturized electrochemical transducers has shown great potential toward simple, rapid, and cost‐effective analysis that can be performed in the field, especially for healthcare, environmental monitoring, and food quality control. For this reason, the number of publications in this field has grown exponentially over the past decade, making it a trending topic in current research. Although great improvement has been achieved in the field of electrochemical biosensing, there are still some challenges to overcome, especially concerning the improvement of sensing materials and miniaturization. In this Review, we summarize some of the most recent advances achieved in POC electrochemical biosensor applications, focusing on new materials and modifiers for biorecognition developed to improve sensitivity, specificity, stability, and response time.

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Section: Aptamer‐based Electrochemical Biosensorsmentioning

confidence: 99%

Section: Aptamer-based Electrochemical Biosensorsmentioning

confidence: 99%

Electrochemical Biosensors in Point‐of‐Care Devices: Recent Advances and Future Trends

et al. 2017

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“…An aptamer-based dopamine sensor has been successfully demonstrated by several groups [79][80][81][82][83][84][85]. In Xu's work, they first modified the carbon nanoparticles on gold electrode, then immobilized thionine on the surface of gold nanoparticles [80].…”

Section: Aptamer-based Sensormentioning

confidence: 99%

Recent Advances in the Detection of Neurotransmitters

Song

2018

Chemosensors

148

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Neurotransmitters are chemicals that act as messengers in the synaptic transmission process. They are essential for human health and any imbalance in their activities can cause serious mental disorders such as Parkinson's disease, schizophrenia, and Alzheimer's disease. Hence, monitoring the concentrations of various neurotransmitters is of great importance in studying and diagnosing such mental illnesses. Recently, many researchers have explored the use of unique materials for developing biosensors for both in vivo and ex vivo neurotransmitter detection. A combination of nanomaterials, polymers, and biomolecules were incorporated to implement such sensor devices. For in vivo detection, electrochemical sensing has been commonly applied, with fast-scan cyclic voltammetry being the most promising technique to date, due to the advantages such as easy miniaturization, simple device architecture, and high sensitivity. However, the main challenges for in vivo electrochemical neurotransmitter sensors are limited target selectivity, large background signal and noise, and device fouling and degradation over time. Therefore, achieving simultaneous detection of multiple neurotransmitters in real time with long-term stability remains the focus of research. The purpose of this review paper is to summarize the recently developed sensing techniques with the focus on neurotransmitters as the target analyte, and to discuss the outlook of simultaneous detection of multiple neurotransmitter species. This paper is organized as follows: firstly, the common materials used for developing neurotransmitter sensors are discussed. Secondly, several sensor surface modification approaches to enhance sensing performance are reviewed. Finally, we discuss recent developments in the simultaneous detection capability of multiple neurotransmitters.

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“…It is however, these hydrophilic oxygenated functional groups which assist in biorecognition during biosensing by promoting favourable interactions with specific analytes [1,[8][9][10], allowing GO to be used as the underlying electrode material for a biosensor towards a number of biological/organic molecules, such as DNA [11,12] and peptides [13]. In many cases where GO is utilised for sensing applications, it is as a component/supporting framework within a more complex catalyst [14,15]. GO's ability to act singularly as a (bio)sensor has yet to be observed within the literature.…”

Section: Introductionmentioning

confidence: 99%

Graphene Oxide Bulk-Modified Screen-Printed Electrodes Provide Beneficial Electroanalytical Sensing Capabilities

et al. 2020

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We demonstrate a facile methodology for the mass production of graphene oxide (GO) bulk-modified screen-printed electrodes (GO-SPEs) that are economical, highly reproducible and provide analytically useful outputs. Through fabricating GO-SPEs with varying percentage mass incorporations (2.5%, 5%, 7.5% and 10%) of GO, an electrocatalytic effect towards the chosen electroanalytical probes is observed, which increases with greater GO incorporated compared to bare/graphite SPEs. The optimum mass ratio of 10% GO to 90% carbon ink produces an electroanalytical signal towards dopamine (DA) and uric acid (UA) which is ca. ×10 greater in magnitude than that achievable at a bare/unmodified graphite SPE. Furthermore, 10% GO-SPEs exhibit a competitively low limit of detection (3σ) towards DA at ca. 81 nM, which is superior to that of a bare/unmodified graphite SPE at ca. 780 nM. The improved analytical response is attributed to the large number of oxygenated species inhabiting the edge and defect sites of the GO nanosheets, which are able to exhibit electrocatalytic responses towards inner-sphere electrochemical analytes. Our reported methodology is simple, scalable, and cost effective for the fabrication of GO-SPEs that display highly competitive LODs and are of significant interest for use in commercial and medicinal applications.

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An electrochemical dopamine aptasensor incorporating silver nanoparticle, functionalized carbon nanotubes and graphene oxide for signal amplification

Cited by 57 publications

References 43 publications

Electrochemical Biosensors in Point‐of‐Care Devices: Recent Advances and Future Trends

Electrochemical Biosensors in Point‐of‐Care Devices: Recent Advances and Future Trends

Recent Advances in the Detection of Neurotransmitters

Graphene Oxide Bulk-Modified Screen-Printed Electrodes Provide Beneficial Electroanalytical Sensing Capabilities

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