An Electrochemical Biosensor for Detection of Cichoric Acid as an Anti-Alzheimer’s Disease Agent in Chicory Samples Based on Setaria-Like Trimetallic Nanodendrites Decorated NH₂-RGO Flakes

Abstract

Chicoric acid (CA), a phenolic acid from chicory, is regarded as a powerful ingredient against oxidative stress and obesity. It's believed to be a promising drug candidate as its healing features prevent memory loss. However, existent methods for CA detection limit its practical applications in purification and further pharmacological study due to lack of accuracy. Therefore, it is crucial to find a forceful approach to precisely analyze cichoric acid for anti-AD research. In this work, we reported a facile method to synthesize Setaria-like trimetallic nanodendrites (G-PP NDs) in a non-compacted core-shell shape with high electrocatalytic activity. In addition, a sensitive biosensor to detect cichoric acid rapidly and accurately has been developed based on G-PP NDs and aminated reduced graphene oxide flakes (NH2-RGO@G-PP NDs). Owing to the great conductivity of NH2-RGO and significant electrochemical performance of G-PP NDs, the obtained sensor exhibited admirable capacities with a low LOD of 0.038 μM. It displayed a high sensitivity, rapid response, and excellent long-term stability, which made it accomplish the measurements CA in chicory samples. The proposed sensor is an auspicious tool for quality control and analysis of metabolism to investigate the beneficial impacts of CA as a functional ingredient to combat AD.

Neurobehavioral, histopathological and immunohistochemical effects of Ginkgo biloba and Cichorium intybus hydro-alcoholic extracts in experimentally alzheimer rats

“…In contrast, in the present study the rats in G, C, and G+C groups showed a protective impact against the neurobehavioral disterbance of ALCL3 when administered prior to ALCL3. These findings consistent with many studies that concluded the powerful antioxidant abilities of Ginko biloba and Cicuriun Intybus each one alone (Rojas et al, 2016; Liu and Guo, 2020; Li et al, 2022) [35,25,23] . The use of all these herbs were conducive to the reduction of inflammatory processes within the nervous system (Hirata et al, 2019) [16] .…”