An electrochemical aptamer biosensor based on “gate-controlled” effect using β-cyclodextrin for ultra-sensitive detection of trace mercury

Li, Jianping; Sun, Mengtao; Wei, Xiao-Ping; Zhang, Lieping; Zhang, Yun

doi:10.1016/j.bios.2015.06.061

Cited by 44 publications

(12 citation statements)

References 31 publications

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“…The magnetic nanoparticles are functionalized with amine groups and then coupled with the CDs through the reaction of the NH 2 and CHO groups, combined with the enzyme and cast onto a magnetic substrate. The ferrocene/β-CD inclusion complex has also been applied in the assembly of aptamer-based sensors [178][179][180]. Aptamers are single-stranded RNA or DNA oligonucleotides and they can bind with high affinity and specificity to their target molecules.…”

Section: Cyclodextrin-based Biosensorsmentioning

confidence: 99%

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Cyclodextrins as Supramolecular Recognition Systems: Applications in the Fabrication of Electrochemical Sensors

et al. 2021

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Supramolecular chemistry, although focused mainly on noncovalent intermolecular and intramolecular interactions, which are considerably weaker than covalent interactions, can be employed to fabricate sensors with a remarkable affinity for a target analyte. In this review the development of cyclodextrin-based electrochemical sensors is described and discussed. Following a short introduction to the general properties of cyclodextrins and their ability to form inclusion complexes, the cyclodextrin-based sensors are introduced. This includes the combination of cyclodextrins with reduced graphene oxide, carbon nanotubes, conducting polymers, enzymes and aptamers, and electropolymerized cyclodextrin films. The applications of these materials as chiral recognition agents and biosensors and in the electrochemical detection of environmental contaminants, biomolecules and amino acids, drugs and flavonoids are reviewed and compared. Based on the papers reviewed, it is clear that cyclodextrins are promising molecular recognition agents in the creation of electrochemical sensors, chiral sensors, and biosensors. Moreover, they have been combined with a host of materials to enhance the detection of the target analytes. Nevertheless, challenges remain, including the development of more robust methods for the integration of cyclodextrins into the sensing unit.

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Section: Cyclodextrin-based Biosensorsmentioning

confidence: 99%

“…The ferrocene/β-CD inclusion complex has also been applied in the assembly of aptamer-based sensors [178][179][180]. Aptamers are single-stranded RNA or DNA oligonucleotides and they can bind with high affinity and specificity to their target molecules.…”

Section: Enantioselective Cyclodextrin-based Electrochemical Sensorsmentioning

confidence: 99%

Cyclodextrins as Supramolecular Recognition Systems: Applications in the Fabrication of Electrochemical Sensors

et al. 2021

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“…Electrochemical biosensors [19,20], plasmon-enhanced photoelectrochemical sensors [21], surface-enhanced Raman spectroscopy (SERS)-based biosensors [22], colorimetric biosensors [23,24], and fluorescent sensors [25,26] have been reported as alternative approaches for mercury ion detection, providing high sensitivity, specificity, and ease of signal read-out. However, these reported systems are still difficult to be used in resource-limited environments due to their relatively complex operations and the requirement for expensive or bulky instruments, such as UV-visible (UV-vis) spectrometers, fluorescence spectrometers, Raman spectrometers, and electrochemical workstations to analyze the assay readouts.…”

Section: Introductionmentioning

confidence: 99%

A Portable Smart-Phone Readout Device for the Detection of Mercury Contamination Based on an Aptamer-Assay Nanosensor

Xiao

et al. 2016

Sensors

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The detection of environmental mercury (Hg) contamination requires complex and expensive instruments and professional technicians. We present a simple, sensitive, and portable Hg2+ detection system based on a smartphone and colorimetric aptamer nanosensor. A smartphone equipped with a light meter app was used to detect, record, and process signals from a smartphone-based microwell reader (MR S-phone), which is composed of a simple light source and a miniaturized assay platform. The colorimetric readout of the aptamer nanosensor is based on a specific interaction between the selected aptamer and Hg2+, which leads to a color change in the reaction solution due to an aggregation of gold nanoparticles (AuNPs). The MR S-phone-based AuNPs-aptamer colorimetric sensor system could reliably detect Hg2+ in both tap water and Pearl River water samples and produced a linear colorimetric readout of Hg2+ concentration in the range of 1 ng/mL–32 ng/mL with a correlation of 0.991, and a limit of detection (LOD) of 0.28 ng/mL for Hg2+. The detection could be quickly completed in only 20 min. Our novel mercury detection assay is simple, rapid, and sensitive, and it provides new strategies for the on-site detection of mercury contamination in any environment.

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“…The authors used GO with gold NPs to modify electrodes for amperometric detection. In another experiment, Li et al (2015) fabricated Hg-biosensors using beta-cyclodxtrin with aptamers. Data on different types of detection of mercury are summarized in Table 1.…”

Section: Electrochemical Methodsmentioning

confidence: 99%

Modern nanobiotechnologies for efficient detection and remediation of mercury

Gaur

Yadav

Kushwah

et al. 2021

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Purpose This information will be useful in the selection of materials and technology for the detection and removal of mercury ions at a low cost and with high sensitivity and selectivity. The purpose of this study is to provide the useful information for selection of materials and technology to detect and remove the mercury ions from water with high sensitivity and selectivity. The purpose of this study is to provide the useful information for selection of materials and technology to detect and remove the mercury ions from water with high sensitivity and selectivity. Design/methodology/approach Different nano- and bio-materials allowed for the development of a variety of biosensors – colorimetric, chemiluminescent, electrochemical, whole-cell and aptasensors – are described. The materials used for their development also make it possible to use them in removing heavy metals, which are toxic contaminants, from environmental water samples. Findings This review focuses on different technologies, tools and materials for mercury (heavy metals) detection and remediation to environmental samples. Originality/value This review gives up-to-date and systemic information on modern nanotechnology methods for heavy metal detection. Different recognition molecules and nanomaterials have been discussed for remediation to water samples. The present review may provide valuable information to researchers regarding novel mercury ions detection sensors and encourage them for further research/development.

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An electrochemical aptamer biosensor based on “gate-controlled” effect using β-cyclodextrin for ultra-sensitive detection of trace mercury

Cited by 44 publications

References 31 publications

Cyclodextrins as Supramolecular Recognition Systems: Applications in the Fabrication of Electrochemical Sensors

Cyclodextrins as Supramolecular Recognition Systems: Applications in the Fabrication of Electrochemical Sensors

A Portable Smart-Phone Readout Device for the Detection of Mercury Contamination Based on an Aptamer-Assay Nanosensor

Modern nanobiotechnologies for efficient detection and remediation of mercury

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