An Elderly Man With Chaotic Sleep Behaviors and Rapidly Progressive Ataxia

Prasertpan, Tittaya; Phuenpathom, Warongporn; Bhidayasiri, Roongroj; Sringean, Jirada

doi:10.1002/mdc3.13537

Cited by 2 publications

(8 citation statements)

References 12 publications

(18 reference statements)

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“…Of 5682 eligible papers, 26 articles 8–33 reporting 28 patients were included. A detailed PRISMA flowchart, the assessment of the risk of bias for each study, and the estimation of frequency in larger cohorts of patients with neurological irAEs are provided in Supporting Information.…”

Section: Resultsmentioning

confidence: 99%

Autoimmune Movement Disorders Complicating Treatment with Immune Checkpoint Inhibitors

Dinoto,

Trentinaglia,

Carta

et al. 2024

Movement Disord Clin Pract

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BackgroundImmune checkpoint inhibitors (ICI) may trigger autoimmune neurological conditions, including movement disorders (MD).ObjectivesThe aim of this study was to characterize MDs occurring as immune‐related adverse events (irAEs) of ICIs.MethodsA systematic literature review of case reports/series of MDs as irAEs of ICIs was performed.ResultsOf 5682 eligible papers, 26 articles with 28 patients were included. MDs occur as a rare complication of cancer immunotherapy with heterogeneous clinical presentations and in most cases in association with other irAEs. Inflammatory basal ganglia T2/fluid attenuated inversion recovery abnormalities are rarely observed, but brain imaging is frequently unrevealing. Cerebrospinal fluid findings are frequently suggestive of inflammation. Half of cases are associated with a wide range of autoantibodies. Steroids and ICI withdrawal usually lead to improvement, even though some patients experienced relapses or a severe clinical course.ConclusionMDs are a rare complication of ICIs that should be promptly recognized to offer patients a correct diagnosis and treatment.

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Section: Resultsmentioning

confidence: 99%

Autoimmune Movement Disorders Complicating Treatment with Immune Checkpoint Inhibitors

Dinoto,

Trentinaglia,

Carta

et al. 2024

Movement Disord Clin Pract

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“…We excluded 739 studies after screening the titles and abstracts and assessed 29 reports for eligibility. Of these, we included six articles [ 18 , 19 , 20 , 21 , 22 , 23 ] and two meeting abstracts [ 24 , 25 ]. After reviewing the references of the included studies, we included two additional articles [ 26 , 27 ].…”

Section: Resultsmentioning

confidence: 99%

“…Five out of six OH studies provided some clinical details to at least partially differentiate between neurogenic and non-neurogenic OH. The authors of [ 24 ] specifically targeted a population with Parkinson’s disease and OH. The one RCT did not provide information on the aetiology [ 23 ].…”

Section: Resultsmentioning

confidence: 99%

“…Five of 10 studies applied HUTS at home [ 20 , 21 , 23 , 24 , 25 ], two in the hospital [ 18 , 22 ] and three started in the hospital and had a follow-up at home [ 19 , 26 , 27 ]. HUTS implementation varied among studies with variable tilting angles (median = 6° (5° to 15°)) as well as various durations (median = 7 days (1 day to 6 months)) ( Figure 2 ).…”

Section: Resultsmentioning

confidence: 99%

“…Some used blocks or chairs underneath the head of the bed ( n = 3) [ 21 , 23 , 27 ], some used wedge mattresses ( n = 1) [ 25 ], or an adjustable hospital bed ( n = 1) [ 18 ], one study had HUTS implemented at home by an engineer ( n = 1) [ 20 ], and one used home-built tools ( n = 1) [ 19 ]. Three studies did not specify the method [ 22 , 24 , 26 ].…”

Section: Resultsmentioning

confidence: 99%

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The Impact of Head-Up Tilt Sleeping on Orthostatic Tolerance: A Scoping Review

Stam

Shmuely

Vries

et al. 2023

Biology

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To systematically summarize the evidence of head-up tilt sleeping (HUTS) on orthostatic tolerance, we conducted a systematic, predefined search in PubMed, OVID Embase, Cochrane and Web of Science. We included studies assessing the effect of HUTS on orthostatic tolerance and other cardiovascular measures and rated the quality with the American Academy of Neurology risk of bias tool. We included 10 studies (n = 185) in four groups: orthostatic hypotension (OH; 6 studies, n = 103), vasovagal syncope (1 study, n = 12), nocturnal angina pectoris (1 study, n = 10) and healthy subjects (2 studies, n = 58). HUTS duration varied (1 day–4 months) with variable inclinations (5°–15°). In two of six OH studies, HUTS significantly improved standing systolic blood pressure. Orthostatic tolerance was consistently enhanced in OH studies with higher angles (≥12°), in 2 out of 3 with smaller angles (5°) but also in one studying horizontal sleeping. In vasovagal syncope, HUTS significantly augmented resilience to extreme orthostatic stress. One study was rated as a class II risk of bias, one of Class II/III and eight of Class IV. The evidence favouring HUTS to improve orthostatic tolerance is weak due to variable interventions, populations, small samples and a high risk of bias. Despite this, we found some physiological signs suggesting a beneficial effect.

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An Elderly Man With Chaotic Sleep Behaviors and Rapidly Progressive Ataxia

Cited by 2 publications

References 12 publications

Autoimmune Movement Disorders Complicating Treatment with Immune Checkpoint Inhibitors

Autoimmune Movement Disorders Complicating Treatment with Immune Checkpoint Inhibitors

The Impact of Head-Up Tilt Sleeping on Orthostatic Tolerance: A Scoping Review

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