An efficient synthesis of pregaliellalactone and desoxygaliellalactone

Diastereoselective Total Synthesis of (−)-Galiellalactone

“…Sterner and Johansson reported the first and efficient synthesis of (−)-galiellalactone and established the absolute configuration of the natural product . However, the stereoselective introduction of a tertiary hydroxyl group remains a formidable task because introduction of an epoxide, as a precursor of the tertiary hydroxyl group, into the hydrindane system of 1 has only been reported with moderate diastereoselectivity . In addition, chemical hydroxylation at the central angular position could not directly elaborate the tertiary hydroxyl group…”