An efficient synthesis of new 2-aminomethyl-1,3,4-oxadiazoles from enantiomeric phenylglycine hydrazides

Synthesis, Characterization and Evaluation of Antimicrobial Activity of Several New N-Substituted Carbazole

“…The structure of compound (1) was confirmed by physical properties which are listed in Table ( (17) and (18) give new compounds (14)(15)(16)(17)(18). These reactions are summarized in Scheme (1).…”

“…From the data it are clear that all compounds possess between height to moderate activity against of yeast (Candidau), while compounds (25) and (27) possess very high activity against one type of bacteria and compounds (2,14,16,19 and 27) possess moderate activity two types of bacteria. As far as compounds (3,7,17 and 27) possess high activity against one types of bacteria while compounds (7, 14, 16, 17, 19 and 24) show inactive against one type of bacteria (E. coli). …”

“…On the hand 2-aminobenzothiazole substituted, 1,3,4-oxadiazoles, and tetrazole constitute a potential class of compounds which possess abroad field of biological interaction [14][15][16]. Many of them exhibit antibacterial, anticonvulsant, anticancer activities and are used to fight infections involving (AIDS) [17]. They are also applied in agriculture as herbicides, fungicides or insecticides [18].…”

Orthoesters: Multiple Role Players in Organic Synthesis

“…The latter six membered rings are generated through the interaction of the active hydroxy group with hydrazide. It is feasible that hydrazides having substituents other than hydroxy at their α‐positions to be used to generate 1,3,4‐oxadiazoles (path ii and iv ). Reactions of the 1,10‐diphenylthiodiacetic acid dihydrazides bearing sulfur at the α position of acid hydrazides with orthoesters furnished bis(1,3,4‐oxadiazol‐2‐yl‐phenylmethyl) sulfides 112 as well as 2‐benzyl‐1,3,4‐oxadiazoles 113 , and 2‐benzoyl‐1,3,4‐oxadiazoles 114 .…”

An effective conversion of N'-ethoxymethylene-2-(N-Boc-amino)propionhydrazides into 2-(1-aminoethyl)-1,3,4-oxadiazoles

“…16 However, the protection of such a group in the α-amino substrate prevents the formation of the latter compounds and the five-membered 2-aminomethyl-1,3,4-oxadiazoles are the only products of the reaction. 17 Such compounds are of the great importance because they could be used as building blocks for macrocyclic systems. Herein, we describe an easy procedure for the synthesis of N'-ethoxymethylene-2-(N-Bocamino)propionohydrazides and its application to the formation of 2-aminoethyl-1,3,4-oxadiazole derivatives.…”