An Efficient Synthesis of Isoxazoles and Pyrazoles under Ultrasound Irradiation

Huang, Zhibin; Li, Lili; Zhao, Yiming; Wang, Huiyuan; Shi, Daqing

doi:10.1002/jhet.2016

Cited by 14 publications

(2 citation statements)

References 29 publications

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“…2) involves the reaction of terminal alkynes with n-BuLi and then aldehydes followed by the treatment with molecular iodine and subsequently with hydroxylamine (Harigae et al 2014). Huang et al (2014) reported an environmentally benign procedure for the synthesis of 3-alkyl-5-aryl isoxazoles (Route f, Fig. 2) under ultrasound radiation without using any catalyst.…”

Section: Synthetic Methodsmentioning

confidence: 99%

The synthetic and therapeutic expedition of isoxazole and its analogs

2018

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Isoxazole, constituting an important family of five-membered heterocycles with one oxygen atom and one nitrogen atom at adjacent positions is of immense importance because of its wide spectrum of biological activities and therapeutic potential. It is, therefore, of prime importance that the development of new synthetic strategies and designing of new isoxazole derivatives should be based on the most recent knowledge emerging from the latest research. This review is an endeavor to highlight the progress in the chemistry and biological activity of isoxazole derivatives which could provide a low-height flying bird's eye view of isoxazole derivatives to the medicinal chemists for the development of clinically viable drugs using this information.

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Section: Synthetic Methodsmentioning

confidence: 99%

The synthetic and therapeutic expedition of isoxazole and its analogs

2018

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“…[35] , and ligand (L) were prepared according to the literature methods. [36][37][38][39][40][41] The elemental analyses were performed with a Perkin-Elmer-2400 CHN analyzer. The electronic absorption spectra of the compounds were recorded with a Perkin-Elmer Lambda 25 absorption spectrophotometer and the solvent used was acetonitrile.…”

Section: Methodsmentioning

confidence: 99%

Pyrazole Based Mono‐ and Di‐Substituted Half Sandwich d⁶ Platinum Group Metal Complexes: Synthesis and Spectral Characterization

Aradhyula

Mawnai

Kollipara

2018

Zeitschrift anorg allge chemie

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Reactions of pyrazole based ligand and halide bridged arene d 6 metal precursors resulted a series of mono and di-substituted pyrazole based half sandwich d 6 metal complexes. In general, they are formulated as [(arene)MLCl 2 ] [M = Ru, arene = benzene (1), p-cymene (2), arene = Cp*, M = Rh (3) and Ir (4)] and [(arene)ML 2 Cl] [M = Ru, arene = benzene (5), p-cymene (6), arene = Cp*, M = Rh (7) and Ir (8)]. All these complexes were characterized by various spectroscopic techniques (IR, 1 H NMR, ESI-MS, and UV/Vis). The molecular struc-* Dr. M. R. Kollipara E-Mail: kmrao@nehu.ac.in [a] Center for Advanced Studies in Chemistry 79tures were confirmed by single-crystal X-ray diffraction technique. Spectroscopic studies revealed that complexation i.e., mono-and disubstitution occurred by the ratio-based reaction between pyrazole ligand and metal precursor through the neutral nitrogen rather than protic nitrogen. In these complexes deprotonation of the protic nitrogen does not occur unlike the other complexes containing pyrazole derivatives, in which the pyrazole ligand is anionic. [(benzene)RuCl 2 L] (1)Yield: 47 %. IR (KBr): ν = 3434 (νN-H), 1639 (νC=C), 1432 (νC=N) cm -1 . 1 H NMR (400 MHz, CDCl 3 ): δ = 12.94 (s, 1 H), 8.26

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ChemInform Abstract: An Efficient Synthesis of Isoxazoles and Pyrazoles under Ultrasound Irradiation.

Huang

Zhao

et al. 2015

ChemInform

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An Efficient Synthesis of Isoxazoles and Pyrazoles under Ultrasound Irradiation. -A series of 5-arylisoxazole (II) and related pyrazole derivatives (III) are synthesized via ultrasound assisted reactions of 3-aminopropenone (I) with hydroxylamine or hydrazine hydrate, respectively. -(HUANG, Z.-B.; LI, L.-L.; ZHAO, Y.-W.; WANG, H.-Y.; SHI*, D.-Q.; J. Heterocycl. Chem. 51 (2014) S1, E309-E313, http://dx.

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An Efficient Synthesis of Isoxazoles and Pyrazoles under Ultrasound Irradiation

Cited by 14 publications

References 29 publications

The synthetic and therapeutic expedition of isoxazole and its analogs

The synthetic and therapeutic expedition of isoxazole and its analogs

Pyrazole Based Mono‐ and Di‐Substituted Half Sandwich d⁶ Platinum Group Metal Complexes: Synthesis and Spectral Characterization

ChemInform Abstract: An Efficient Synthesis of Isoxazoles and Pyrazoles under Ultrasound Irradiation.

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An Efficient Synthesis of Isoxazoles and Pyrazoles under Ultrasound Irradiation

Cited by 14 publications

References 29 publications

The synthetic and therapeutic expedition of isoxazole and its analogs

The synthetic and therapeutic expedition of isoxazole and its analogs

Pyrazole Based Mono‐ and Di‐Substituted Half Sandwich d6 Platinum Group Metal Complexes: Synthesis and Spectral Characterization

ChemInform Abstract: An Efficient Synthesis of Isoxazoles and Pyrazoles under Ultrasound Irradiation.

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Pyrazole Based Mono‐ and Di‐Substituted Half Sandwich d⁶ Platinum Group Metal Complexes: Synthesis and Spectral Characterization