An efficient synthesis of highly functionalized novel chromeno[4,3-b]pyrroles and indolizino[6,7-b]indoles as potent antimicrobial and antioxidant agents

Synthesis of Chromen[4,3‐b]pyrrolidines by Intramolecular 1,3‐Dipolar Cycloadditions of Azomethine Ylides: An Experimental and Computational Assessment of the Origin of Stereocontrol

“…[14][15][16][17][18][19][20] However, the isolation of a third stereoisomer 16 in high percentages was unexpected. For the analysis of the relative configuration single crystal X-ray diffraction and different NMR experiments were combined.…”

“…This structural motif [1,2] is present in compound 1, [3] and constrained analogs of methoctramine 2, [ 4 ] which are antagonist of muscarinic acetyl choline receptors (mAChR). The diazo-derivative 3, [5] is a key precursor in the preparation of new amino azachromenes displaying photochromic properties ( Figure 1).…”

<strong>Ionic Liquid</strong><strong> Mediated Synthesis Of Novel </strong><strong>Chromone-Pyrimidine Coupled Derivatives.</strong>

“…This compound have become indispensable structural units that are useful in medicinal chemistry displaying profiles such as anticancer [3], antioxidant [4], antiplasmodial [5], antimalarial [6], antirhinovirus [7], antifungal [8] and antibacterial [9]. 4-Oxo-4H-chromen-3-carbaldehyde (3-formylchromone) a useful precursor for the synthesis of several biological active compounds owing to the presence of an unsaturated keto function, a conjugated second carbonyl group at C-3, and an electrophilic centre at C-2.…”

Comparative Evaluation of Bactericidal, Antifungal And Antioxidant Properties of Biologically Active Schiff Bases of Substituted Indoles And Their Inclusion Complexes With Β-CD

“…Schiff bases having indole moiety as active core have considered as versatile pharmacophores because they possess effective pharmacological activities such as antiviral [1], antibacterial [2], anti-inflammatory [3][4], antifungal [5], antioxidant [6], anti-tubercular [7], anticancer [8] etc.…”