An Efficient Synthesis of Five-membered Cyclic Ethers from 1,3-Diols Using Molecular Iodine as a Catalyst

Synthesis of Carboxylic Acids, Esters, Alcohols and Ethers Containing a Tetrahydropyran Ring Derived from 6-Methyl-5-hepten-2-one

“…When the solvent was changed to hexane or diethyl ether, cyclization did not occur entries 3 and 4 . We previously reported that acetonitrile was a suitable solvent for the solution reaction using iodine as a catalyst 10 and similar results were observed in this work. Boron trifluoride diethyl etherate was used as an acidic catalyst.…”

“…Addition of hydrogen to the double bond forms a tertiary carbocation, which an electron pair from the hydroxyl group then attacks the tertiary carbocation producing a tetrahydropyran ring. In the case of iodine, hydrogen iodide, which is initially formed by the interaction of iodine with the hydroxyl group, acts as an acidic catalyst 10 .…”

Amidation of Alcohols with Nitriles under Solvent-free Conditions Using Molecular Iodine as a Catalyst

“…In the present study, iodine was investigated as a catalyst for the reaction of alcohols with nitriles. Recently, iodine has been investigated as a potential efficient catalyst in several organic reactions because it has low toxicity [6][7][8][9][10][11][12][13][14][15][16][17][18] . In this study, we also investigated solvent-free conditions, from the viewpoint of green chemistry .…”

Synthesis of Cinnamyl Ethers from .ALPHA.-Vinylbenzyl Alcohol Using Iodine as Catalyst

“…Iodine is easy to handle and has low toxicity, and it has been found to be an efficient catalyst in several organic reactions [6][7][8][9][10][11][12][13][14][15][16] . We previously reported iodine to be an effi cient catalyst in the intramolecular etherifi cation of 1,3-diols 17 .…”