An Efficient Synthesis of Chromeno[4,3-d]isoxazolo[5,4-b]pyridin-6-one Derivatives

Abstract

A series of chromeno [4,3-d]isoxazolo [5,4-b]pyridin-6-one derivatives were easily and efficiently synthesized by the reaction of 3-acyl-2H-chromen-2-ones with isoxazol-5-amine in acetic acid. Some synthesized compounds were evaluated for their antiproliferative properties in vitro against cancer cells, and these compounds were found to have some activities.