An Efficient Synthesis of Bis-indolylindane-1,3-diones, Indan-1,3-diones, and Indene-1,3(2H)-denies Using [Hbim]BF₄ Ionic Medium

Abstract

We prepared a brand new molecule in one step for the synthesis of bis-indolylindane-1,3-dione and indan-1,3-diones from the reaction of ninhydrin and 3 substituted/unsubstituted indoles using [Hbim]BF4 ionic liquid in excellent yields. The method was also used for the synthesis of novel indene-1,3(2H)-denies derivatives.

One-pot, mild and efficient multicomponent synthesis of novel various spiro-nitrogen heterocycle compounds

“…The remaining residue was recrystallized and poured from ethanol. [1,2-b]quinoxaline-11,2'- [1,3]oxazino [2,3-a]isoquinoline]-3',4'dicarboxylate (5a). Yellow powder; m.p.…”

“…Yellow powder; m.p. = 240; yield: 0.448 g (89%); IR (KBr) (νmax/cm -1 ) = 1700, 1736 (2C=O); 1 H NMR: δ 3.23 (3H, s, MeO), 4.07 (3H, s, MeO), 5.91 (1H, d, 3 J = 7.9 Hz, =CH), 6.57 (1H, d, 3 J = 7.9 Hz, =CH), 6.88 (1H, s, CH), 7-8.40 (12H, m, =CH); 13 [1,2-b]quinoxaline-11,3'- [1,3]oxazino [3,2-a]quinoline]-1',2'dicarboxylate (5c). Yellow powder; m.p.…”

“…Heterocyclic chemistry is one of the most complex branches of chemistry and heterocyclic compounds, the largest and most diverse family of chemical compounds. The heterocyclic compounds have a stable structure that cannot be easily hydrolyzed or polymerized [1][2][3]. The heterocyclic compounds are a broad category of ring compounds that contain one or more noncarbon atoms, including nitrogen, oxygen, sulfur, or phosphorus in their structure [4][5][6].…”