An efficient route towards R-2-phenoxypropionic acid synthesis for biotransformative production of R-2-(4-hydroxyphenoxy)propionic acid

Zhou, Haïyan; Li, Yi-Zuo; Jiang, Rui; Wang, Xianlin; Wang, Yuan-Shan; Xue, Ya‐Ping; Zheng, Yu‐Guo

doi:10.1016/j.cjche.2020.06.013

Cited by 2 publications

(2 citation statements)

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“…intermediate in the synthesis of pesticides and pharmaceuticals, especially the chirally pure 2-chloropropionic acid precursors for synthesizing many chiral drugs (Nguyen et al, 2021;Zhou et al, 2021). However, these haloacids produce chlorinated organic contaminants owing to extensive use and improper disposal.…”

Section: Environmental Bioremediationmentioning

confidence: 99%

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Mini Review: Advances in 2-Haloacid Dehalogenases

et al. 2021

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The 2-haloacid dehalogenases (EC 3.8.1.X) are industrially important enzymes that catalyze the cleavage of carbon–halogen bonds in 2-haloalkanoic acids, releasing halogen ions and producing corresponding 2-hydroxyl acids. These enzymes are of particular interest in environmental remediation and environmentally friendly synthesis of optically pure chiral compounds due to their ability to degrade a wide range of halogenated compounds with astonishing efficiency for enantiomer resolution. The 2-haloacid dehalogenases have been extensively studied with regard to their biochemical characterization, protein crystal structures, and catalytic mechanisms. This paper comprehensively reviews the source of isolation, classification, protein structures, reaction mechanisms, biochemical properties, and application of 2-haloacid dehalogenases; current trends and avenues for further development have also been included.

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Section: Environmental Bioremediationmentioning

confidence: 99%

“…L-2-chloropropionic acid is an important precursor in the synthesis of herbicides and pesticides (Zhou et al, 2021). D-DEX specifically hydrolyzes D-2-chloropropionic acid in racemic 2-chloropropionic acid; L-2-chloropropane acid is therefore obtained with high enantiomeric purity by separation (Gong et al, 2018).…”

Section: Fine Chemical Synthesismentioning

confidence: 99%