“…The main challenge in synthesis is to oxidize the emodin to rhein in a simple and reliable way. Oxidation via Jones oxidation was reported to generate significant toxicity to the environment (Waser et al, 2005) KMnO 4 -KOH or KMnO 4 -PyH, as oxidative agents , produces many byproducts. We chose five oxidative systems for comparison, namely, H 2 O 2 -HAc, CrO 3 -HAcAc 2 O, KMnO 4 -PyH-TBAB, KMnO 4 -PyH-PEG600, and KMnO 4 -PyH-TMAB.…”