An Efficient Protocol for the Production of Pymetrozine via a New Synthetic Strategy

Zhou, Qifan; Du, Fangyu; Shi, Yajie; Liu, Wenqiang; Liu, Dongdong; Chen, Guoliang

doi:10.3184/174751918x15341514233168

Cited by 3 publications

(1 citation statement)

References 13 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Approaches to the heterocyclic core of 1,2,4-triazin-3(2 H )-ones include the use of hydrazine as a nucleophile in ring-opening reactions of oxadiazol-2-one moieties, condensation chemistry with dicarbonyl derivatives, or addition onto isocyanates . Two new approaches to triazinones were recently reported.…”

Section: Introductionmentioning

confidence: 99%

Synthesis of 1,2,4-Triazinones Exploiting the Reactivity of Diazadiene and N-Isocyanate Intermediates

et al. 2023

View full text Add to dashboard Cite

1,2,4-Triazinones are useful compounds, but their synthesis can be challenging. Herein, we report a strategy to build 1,2,4-triazinones using α-bromohydrazones to access diazadienes and exploiting their ability to undergo facile substitution with nitrogen nucleophiles. The N-isocyanate intermediate formed in situ can then undergo cyclization to give the desired triazinones. This provides access to products with various substituents at the 4-position, and with suitable hydrazone precursors (R 2 = Ph), the cascade reaction yields 1,2,4-triazin-3(2H)-ones at room temperature.

show abstract

Section: Introductionmentioning

confidence: 99%

Synthesis of 1,2,4-Triazinones Exploiting the Reactivity of Diazadiene and N-Isocyanate Intermediates

et al. 2023

View full text Add to dashboard Cite

show abstract

Unravelling the Unexpected: Mechanistic Insights and DFT Studies on the Formation of Azine from N-Acylhydrazones

Abdulwahab,

Tang,

Yehye

et al. 2024

Russ J Gen Chem

View full text Add to dashboard Cite

Optimization of pretreatment in pymetrozine production wastewater via reactive distillation and side-stream distillation methods with response surface methodology

Chen

Wang

Cai

et al. 2020

Water Science and Technology

View full text Add to dashboard Cite

Lots of highly concentrated saline organic wastewater is produced during the pymetrozine production process, causing environmental pollution and waste of resources if discharged directly. Research on actual pymetrozine wastewater treatment is quite scarce. Existing treatment methods of pesticide wastewater usually have disadvantages of long treatment time, low processing efficiency and low recovery rate. To solve these problems, a pretreatment process for pymetrozine wastewater was studied based on material recovery and pollutant degradation. The ammonia conversion process was experimentally investigated by reactive distillation. The reaction product vapor was neutralized and then separated by side-stream distillation. Aspen Plus and response surface methodology were employed to simulate and optimize the operating conditions. Box-Behnken design was used to investigate the individual and interaction effects on methanol purification and sodium acetate removal. Experimental study was carried out on the basis of theoretical simulation data. The result showed that the optimized methanol content on tower top was 99.28% with a yield of 99.95% and methanol content of side withdrawal was 0.01%. The process can be applied for pesticide wastewater treatment to recycle high purity chemical materials, and meets the national sewage comprehensive emission standard.

show abstract

An Efficient Protocol for the Production of Pymetrozine via a New Synthetic Strategy

Cited by 3 publications

References 13 publications

Synthesis of 1,2,4-Triazinones Exploiting the Reactivity of Diazadiene and N-Isocyanate Intermediates

Synthesis of 1,2,4-Triazinones Exploiting the Reactivity of Diazadiene and N-Isocyanate Intermediates

Unravelling the Unexpected: Mechanistic Insights and DFT Studies on the Formation of Azine from N-Acylhydrazones

Optimization of pretreatment in pymetrozine production wastewater via reactive distillation and side-stream distillation methods with response surface methodology

Contact Info

Product

Resources

About