An efficient one-pot synthesis of tetra-substituted pyrroles

Microwave‐Assisted, One‐Pot Three‐Component Synthesis of 6‐(Pyrrolyl) Coumarin/Quinolone Derivatives Catalyzed by In(III) Chloride

“…The treatment of the mixture of 1 a (1.0 equiv), 2 a (1.2 equiv) and 3 a (1.2 equiv) under heating following the literature reported method resulted 4 a in a trace amount as revealed by the LCMS data ( m/z = 446.0 [M + H] + ) of the crude reaction mixture (Table , entry 1).…”

Simple and Multi-Component Synthesis of Pyrrole Heterocycles

“…The crucial steps in the synthesis, reduction (DIBAH) of the corresponding pyrrolyl esters (33) to the corresponding Figure 1 Showing the different reagents in reactants (15)(16)(17)(18) and products (20)(21)(22)(23). These synthetic schemes use inexpensive reagents and provide pure products after simple purification processes.…”

“…These reactions could precede via domino Michel addition/cyclization process. [20] This reaction protocol being one-pot three components, fast, efficient mild and metal-free synthesis of substituted pyrrole heterocycles ( Table 6). Bandyopadhyay et al [21] carried out the simple ultrasoundassisted eco-friendly practical method for the synthesis of N-substituted pyrroles (66) [R=Ph, 4-OMeC 6 H 4 , Py, naphthyl, trinaphthyl, adamantly, crysenyl, pyrenyl, 1, 10-phenanthrolinyl, phenanthrenyl by reacting 2, 5-dimethoxytetrahydrofuran (64) with various amines (65) [R as defined above] in the presence of catalytic amounts (5 mol%) of bismuth nitrate pentahydrate under solvent free conditions.…”

Nitroalkane‐Mediated Multicomponent Synthesis of β‐Enaminones

“…Among various reported MCRs, the one‐pot coupling of 1,3‐diketone, aldehyde, and amine in different solvents that gives a pseudo four component product (Scheme ) has been considered to be one of the most frequently employed MCRs . Nevertheless, when aldehyde is replaced by the corresponding nitrostyrene, the major product for this MCR was found to be the β‐enaminones ,. To the best of our knowledge, no effort has been made to synthesize β‐enaminones from commercially available 1,3‐diketone, aldehyde, and amine.…”