An efficient one‐pot solvent‐free synthesis of 2,3‐dihydroquinazoline‐4(1H)‐ones via Al/Al₂O₃ nanoparticles

Abstract

An efficient one-pot, solvent-free method is reported for the synthesis of 2-phenyl-2,3-dihydroquinazoline-4(1H)-one as well as its o-Cl, o-OMe, m-Br, m-NO 2 , p-OH, p-NO 2 , p-CN, p-PhCH 2 O, p-Cl, p-F, p-Br, p-Me, and o,m-dichloro derivatives, using our ''as-prepared'' arc discharge fabricated Al/Al 2 O 3 nanoparticles. Compared with our previous report and other known methods, this route gives higher yields with shorter reaction times, whereas its green catalyst appears recyclable at least four times-with minor decrease in its catalytic activity, under mild conditions.

Exploration of catalytic performance of nano-La2O3 as an efficient catalyst for dihydropyrimidinone/thione synthesis and gas sensing

“…Organic reactions that take place using metal oxide nanoparticles take place smoothly due to high surface area and presence of active adsorption sites. Variety of nano-catalysis has been employed for the synthesis of organic compounds [7][8][9]. At the same time, ultrasonic irradiation has been comprehensively employed in organic conversions in recent years [10].…”

Application of Nanocatalysts in Multi-Component Reactions

“…In 2010, Kassaee and co-workers have been employed Al/Al 2 O 3 NPs as an effective catalyst in the onepot multi-component synthesis of 2,3-dihydroquinazolin-4(1H)-ones. 17 In this study, isatoic anhydride was reacted with aromatic aldehydes and ammonium acetate in the presence of Al/Al 2 O 3 NPs under solvent-free conditions and the products were formed in excellent yields in short reaction times. The recovered catalyst was reused four times but slight decrease was observed in the yield of the products (Scheme 16).…”

2,3-Dihydroquinazolin-4(1H)-one as a privileged scaffold in drug design

“…In addition, the magnetic properties of NPs make complete recovery of the catalyst possible by means of an external magnetic eld. 87 As reported in Table 3, some metal and metal oxide NPs, exhibiting high surface/volume ratio, quantum size and quantum tunnel effects, efficiently catalyzed the one-pot three-component synthesis of DHQs, in 0.5-6 h. [88][89][90][91] Nanosized aluminum nitride, a non-toxic, low-cost and highly pure powder, was used as a solid source of ammonia in the multicomponent synthesis of DHQs. 92 Hydroxyapatite (HAP) NPs show ion-exchange ability, adsorption capacity, and acid-base properties.…”