An efficient nano CuO-catalyzed synthesis and biological evaluation of quinazolinone Schiff base derivatives and bis-2,3-dihydroquinazolin-4(1H)-ones as potent antibacterial agents against Streptococcus lactis

Zhang, Jin; Cheng, Pei; Ma, Yangmin; Liu, Jia; Miao, Zhi Wei; Ren, Decheng; Fan, Chunhai; Liang, Ming; Liu, Le

doi:10.1016/j.tetlet.2016.10.047

Cited by 19 publications

(8 citation statements)

References 36 publications

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“…The Amadori product is formed through rearrangements of Schiff base . The NBT assay results indicated that the Amadori product in HSA incubated with 3BHB+Glc was significantly lower than HSA incubated with Glc alone (Figure ).…”

Section: Discussionmentioning

confidence: 96%

“…The generation of Amadori product is initiated by formation of covalent bonds between free amino group of proteins and carbonyl group of sugars, resulting in extensive changes in the protein structure . According to the results of the free lysine content assay (TNBSA test), the amount of modified lysine residues of HSA incubated with 3BHB+Glc was higher than that of HSA incubated with Glc or 3BHB alone (Figure ).…”

Section: Discussionmentioning

confidence: 98%

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Determination of Amadori Product in Glycated Human Serum Albumin by Spectroscopy Methods

2018

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The Amadori product is a stable intermediate in the glycation process, and its increased formation is a marker of hyperglycemia in diabetes mellitus. Its accumulation in the body contributes to pathological complications of diabetes including diabetic nephropathy and retinopathy, and cardiovascular diseases. In this study the effect of 3‐β‐hydroxybutyrate on the production of Amadori products and structural changes of human serum albumin (HSA) after incubation with glucose was investigated using FT‐IR, circular dichroism (CD), and UV‐visible and fluorescence spectroscopy. Our results showed that the production of Amadori products in HSA incubated with glucose was decreased in the presence of 3‐β‐hydroxybutyrate. The glycation‐mediated alterations in HSA secondary and tertiary structures were also reduced in the presence of 3‐β‐hydroxybutyrate. These changes were attributed to reduced formation of glucose covalent bonds with the HSA lysine residues in the presence of 3‐β‐hydroxybutyrate. Thus, 3‐β‐hydroxybutyrate reduced the production of Amadori products by reacting with lysine residues and decreasing HSA covalent modifications by glucose.

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Section: Discussionmentioning

confidence: 96%

Section: Discussionmentioning

confidence: 98%

Determination of Amadori Product in Glycated Human Serum Albumin by Spectroscopy Methods

2018

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“…Sadeghi et al [76] described ZnO nanoparticles as an efficient and reusable catalyst for the synthesis of a series of quinoxaline derivatives (24) via the condensation between various 1,2-diketones (6) and 1,2-diamines (9) under solvent-free condition at room temperature (Scheme 3). …”

Section: Synthesis Of Quinoxalinesmentioning

confidence: 99%

“…in nano form, have drawn considerable attention as efficient, environmentally sustainable, heterogeneous catalysts and have found immense applications in various organic transformations that include C-H funtionalizaion [20], synthesis of 2-aminobenzimidazoles, Fig. 1 Some of the marketed drugs containing heterocycles 2-aminobenzothiazoles, benzoxazoles [21], tetrahydrobenzofurans [22], α-aminophosphonate [23], bis-2,3-dihydroquinazolin-4(1H)-ones [24], 1,4-substituted 1,2,3-triazoles [25], xanthenes [26], pyrano [2,3-d]pyrimidines, 4H-chromenes, and dihydropyrano [3,2-c]chromenes [27], substituted pyridines [28], quinoxalin-2-amine [29] and many more [30,31].…”

Section: Introductionmentioning

confidence: 99%

Recent developments on nano-ZnO catalyzed synthesis of bioactive heterocycles

Banerjee

2017

J Nanostruct Chem

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Last decade has seen tremendous applications of nano-ZnO as a mild, cheap, efficient, commercially available, environmentally benign, non-toxic, reusable, heterogeneous catalyst for the various organic transformations. The present review summarizes the applications of nano-ZnO as an efficient heterogeneous catalyst for the synthesis of diverse biologically relevant heterocycles reported so far. Graphical abstract Nano

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“…Schiff bases have attracted the intensive attentions of researchers in many fields of chemical, pharmaceutical, and life sciences in recent years( 10 11 12 ). This motif contains the toxophoric group (-HC=N) which could be formed by reaction of primary amines with carbonyl compounds in dry glacial acetic acid by nucleophilic addition( 13 ). Farang, et al .…”

Section: Introductionmentioning

confidence: 99%

Synthesis, characterization, cytotoxic screening, and density functional theory studies of new derivatives of quinazolin-4(3H)-one Schiff bases

et al. 2017

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A series of novel derivatives of quinazolinone Schiff bases were synthesized from benzoic acid starting material and evaluated for potential cytotoxic activities against the human breast adenocarcinoma (MCF-7) and the human colon adenocarcinoma (HT-29) cell lines. Compared to the reference drug, these compounds showed good cytotoxic activities against studied cell lines especially compounds 4d and 4e. The ground-state geometries of these compounds (4a-g) were optimized at the B3LYP/6–31G* density functional theory (DFT) level. Then maximum absorptions electron affinity, ionization potential, electronegativity (χ), energy gap (Egap), hardness (η), softness (S), electrophilicity (ω), and electrophilicity index (ωi) were calculated and discussed. The quantitative structure-activity relationship (QSAR) properties including the physicochemical parameters were also evaluated and studied. The computed properties of our novel synthesized compounds were compared with erlotinib compound.

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An efficient nano CuO-catalyzed synthesis and biological evaluation of quinazolinone Schiff base derivatives and bis-2,3-dihydroquinazolin-4(1H)-ones as potent antibacterial agents against Streptococcus lactis

Cited by 19 publications

References 36 publications

Determination of Amadori Product in Glycated Human Serum Albumin by Spectroscopy Methods

Determination of Amadori Product in Glycated Human Serum Albumin by Spectroscopy Methods

Recent developments on nano-ZnO catalyzed synthesis of bioactive heterocycles

Synthesis, characterization, cytotoxic screening, and density functional theory studies of new derivatives of quinazolin-4(3H)-one Schiff bases

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