Offshore structures are exposed to random wave loading in the ocean environment, and hence the probability distribution of the extreme values of their response to wave loading is required for their safe and economical design. In most cases, the dominant load on offshore structures is due to wind-generated random waves where the ocean surface elevation is defined using appropriate ocean wave energy spectra. Several spectral models have been proposed to describe a particular sea state that is used in the design of offshore structures. These models are derived from analysis of observed ocean waves and are thus empirical in nature. The spectral models popular in the offshore industry include Pierson-Moskowitz spectrum and JONSWAP spectrum. While the offshore industry recognizes that different methods of simulating ocean surface elevation lead to different estimation of design wave height, no systematic investigation has been conducted. Hence, the aim of this study is to investigate the effects of predicting the 100-year responses from various wave spectrum models. In this paper, the Monte Carlo time simulation (MCTS) procedure has been used to compare the magnitude of the 100-year extreme responses derived from different spectral models. Additionally, the linear random wave theory (LRWT) was implemented to simulate the offshore structural responses due to random wave loading. The models have been tested for three different environmental conditions represented by Hs = 15m, 10m and 5m respectively. The accuracy of the predictions of the 100-year responses from Pierson-Moskowitz and JONSWAP spectrums will then be investigated.