An Efficient Method Based on the Photothermal Effect for the Release of Molecules from Metal Nanoparticle Surfaces

Abstract

Please release me: The heat generated when metal nanoparticles absorb light results in a significant increase in the temperature of the environment around the particles and is used to selectively break bonds within a molecular system anchored to the nanoparticle surface (see picture). This process represents an advantageous and more universal method to deliver chemicals locally, while avoiding excessive tissue damage.

Fabrication and characterization of superparamagnetic and thermoresponsive hydrogels based on oleic-acid-coated Fe3O4 nanoparticles, hexa(ethylene glycol) methyl ether methacrylate and 2-(acetoacetoxy)ethyl methacrylate

“…As a result, these novel nanocomposite magnetoresponsive and thermoresponsive conetworks may be used potentially in the biomedical field as externally actuated drug delivery systems or as agents for electromagnetic hyperthermia treatment. Alternatively, properly designed thermoresponsive conetworks capable of performing sharply defined drug release via photothermal treatment [24] could be highly beneficial in many biomedical applications.…”

Syntesis and Crystalline Structure of the Exo-3,6-Dimethyl-3,6-Epoxi-1,2,3,6-Tetrahydrophtlalimide and Its N-Bromodecyl Analog: Two Thermally Labile Diels-Alder Adducts

“…B. S.et al 9 . Our 1 H NMR data are in accordance with the chemical shifts and multiplicities previously reported for that analog compound.…”

“…Also, Bakhtiari et al used this DA adduct as a linker between gold nanoparticles and fluorescein dye, proving that the thermally labile adduct can release the dye under photothermal conditions (i.e. thermal or light irradiation) 9 . As a thermally labile protecting group has been included in synthetic schemes to provide for peptides, peptoids and peptide nucleic acids 10 and Maleimide functionalized gold nanoparticles 11,12 .…”

Self‐Assembled DNA Nanostructures for Drug Delivery

“…Au, Ag) display intriguing optical and photothermal conversion properties. [89][90][91][92][93][94][95] Liu [96] and colleagues coated the surface of carboxylated polystyrene spheres with gold nanoshells, which absorbed NIR light and resulted in the local rise in temperature. As a consequence, the tumor cells were heated up quickly with an average inhibition rate over 55%.…”