1998
DOI: 10.1016/s0040-4039(98)01995-9
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An efficient homogeneous catalytic enantioselective synthesis of α-amino acid derivatives

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Cited by 141 publications
(47 citation statements)
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“…Although levels of induction are not affected by stirring rate, effective stirring is crucial in order to obtain rapid reaction. [16] As can be seen from the results (Table 1), increasing the concentration of catalyst (4) has a positive result on the ee (Entries 1 and 2). In both cases, a high conversion (Ͼ 90%) of the […”
Section: Resultsmentioning
confidence: 82%
“…Although levels of induction are not affected by stirring rate, effective stirring is crucial in order to obtain rapid reaction. [16] As can be seen from the results (Table 1), increasing the concentration of catalyst (4) has a positive result on the ee (Entries 1 and 2). In both cases, a high conversion (Ͼ 90%) of the […”
Section: Resultsmentioning
confidence: 82%
“…The reactions shown in Scheme 1 and all further schemes were optimized with synthons of natural isotopic abundance. The starting materials Ϫ tert-butyl benzophenoneimine glycinate (7), dimethylallyl bromide (8), and the chiral cinchona-derived phase-transfer catalyst [26,27] Ϫ are all commercially available. In order to prepare homoserine 10, 7 was dissolved in a toluene/chloroform mixture and treated with 8 in the presence of 0.01 equiv.…”
Section: Synthesismentioning
confidence: 99%
“…A homogeneous alkylation of 10 using the phosphazene base BEMP was also evaluated, [30] but this resulted in lower yields and ee values (83 % yield, 86 % ee).…”
Section: Introductionmentioning
confidence: 99%