An efficient, high yield protocol for the one-pot synthesis of dihydropyrimidin-2(1H)-ones catalyzed by iodine

One-pot synthesis of highly substituted imidazoles using molecular iodine: A versatile catalyst

“…Owing to several advantages, such as inexpensive non-toxic, eco-friendly nature, iodine has been used as a readily available catalyst in the investigation of different organic reactions [23]. Development of efficient, selective and eco-friendly methods for application in complex organic preparations is the ultimate goal of several research groups, including ours [24], so in continuation of our work here we wish to report the eco-friendly a One equiv benzil 1:1 equiv benzaldehyde 3a:2.5 equiv NH 4 OAc 2 at room temperature.…”

Novel alkynyl substituted 3,4-dihydropyrimidin-2(1H)-one derivatives as potential inhibitors of chorismate mutase

“…Thus, an overall four component reaction was developed involving a sequential phosphorous acid-mediated Biginelli followed by Cu-free Sonogashira or Heck or Suzuki reaction [26]. The use of elemental iodine on the other hand has been explored for successful Biginelli reaction earlier [27]. In view of the easy availability and inexpensive as well as safer Insert Scheme 1 here.…”

One-pot multi-component synthesis of tetrahydroquinazolinones via Biginelli condensation using molecular iodine as a catalyst

“…Because of global environmental concern and social sustainable development, green synthesis is a current hot topic [12].Molecular iodine as an inexpensive, nontoxic, readily available catalyst has been used successfully in the Biginelli reaction [13,14] affording the corresponding products in excellent yields with high selectivity [13][14][15][16]. The mild Lewis acidity associated with iodine enhanced its usage in organic synthesis to realize several organic transformations using stoichiometric levels to catalytic amounts.…”