In this article, an efficient fourth-order accurate numerical method based on Padé approximation in space and singly diagonally implicit Runge-Kutta method in time is proposed to solve the time-dependent onedimensional reaction-diffusion equation. In this scheme, we first approximate the spatial derivative using the second-order central finite difference then improve it to fourth-order by applying Padé approximation. A three stage fourth-order singly diagonally implicit Runge-Kutta method is then used to solve the resulting system of ordinary differential equations. It is also shown that the scheme is unconditionally stable, and is suitable for stiff problems. Several numerical examples are solved by the scheme and the efficiency and accuracy of the new scheme are compared with two widely used high-order compact finite difference methods.