An efficient cocrystallization strategy for separation of dihydromyricetin from vine tea and enhanced its antibacterial activity for food preserving application

Xia, Yanming; Lü, Yan; Qian, Shuai; Zhang, Jianjun; Gao, Yuan; Wei, Yuanfeng; Heng, Weili

doi:10.1016/j.foodchem.2023.136525

Cited by 5 publications

(1 citation statement)

References 38 publications

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“…Common crystallization methods include reaction, antisolvent, cooling, evaporation, and melt crystallization. Most chemical products or intermediates exist in a crystalline form, and crystallization is used to produce a wide variety of chemical, pharmaceutical, and food products . The main driving force for crystal nucleation and growth is supersaturation, which can be achieved by cooling, evaporation, and antisolvent methods, among others. , Compared to other purification processes, crystallization offers by high recovery, good product quality, high yield, low energy consumption, good operability, and good stability .…”

Section: Introductionmentioning

confidence: 99%

Thermodynamics, Solubility, and Crystallization of 1,5-Pentylenediamine Hydrochloride in Mixed Solvent Systems

Li,

Hu,

et al. 2024

Ind. Eng. Chem. Res.

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The properties of 1,5-pentylenediamine hydrochloride (PDAH), a precursor of biobased pentamethylene diisocyanate (PDI), have a key influence on the PDI quality. In this study, the thermodynamics, solubility, and crystallization of PDAH in ethanol−water mixed solutions (0−100 wt % ethanol) were investigated. First, the solubility was investigated at 273.15− 323.15 K by a solvent evaporation method and characterized using the Apelblat, polynomial empirical, λh, and the modified van't Hoff−Jouyban−Acree equations. The activity coefficient increased with decreasing polarity and decreasing temperature. Thermodynamic analysis shows that dissolution is always spontaneous if the solution is not saturated. The surface tension and surface entropy factor increased with decreasing polarity and decreasing temperature. Finally, the crystallization of PDAH in an ethanol−water solution was studied by comparing cooling crystallization, antisolvent crystallization, and three combined cooling and antisolvent crystallization processes. The best crystallization process was found to be antisolvent, followed by cooling crystallization, with a 66.72% one-time yield and 99% purity. This study provides an important reference for the crystallization separation of other biobased products.

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Section: Introductionmentioning

confidence: 99%

Thermodynamics, Solubility, and Crystallization of 1,5-Pentylenediamine Hydrochloride in Mixed Solvent Systems

Li,

Hu,

et al. 2024

Ind. Eng. Chem. Res.

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Dihydromyricetin alleviates inflammatory bowel disease associated intestinal fibrosis by inducing autophagy through the PI3K/AKT/mTOR signaling pathway

Wang,

Li,

et al. 2023

Naunyn-Schmiedeberg's Arch Pharmacol

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Objective: Intestinal brosis is a common complication of in ammatory bowel disease and is characterized by tissue stiffening and luminal narrowing. Dihydromyricetin (DHM) can alleviate liver brosis and renal interstitial brosis by inducing autophagy. However, whether DHM can alleviate intestinal brosis remains unclear. This study aimed to evaluate the role and mechanism of action of DHM in in ammatory bowel disease-associated intestinal brosis .Methods: Mice were administered Dextran sulphate Sodium (DSS) in drinking water to induce in ammatory bowel disease-associated intestinal brosis. HE staining, qPCR and Western blotting were used to analyze colon in ammation. Masson' s trichrome staining, qPCR, Western blotting and immuno uorescence staining were used to evaluate the severity of brosis. Transmission electron microscopy and Western blotting were used to assess the activation of autophagosomes. The human colonic broblast line CCD-18Co, was cultured in the presence of TGF-β1 to develop a brotic phenotype.Immuno uorescence staining, Western blotting and qPCR were used to assess the alteration of brosis markers and used to investigate whether DHM-induced autophagy was involved in the inactivation of CCD-18Co cells. Additionally, the role of the PI3K/AKT/mTOR pathway was investigated.Results: DHM alleviated intestinal in ammation and inhibited the progression of intestinal brosis. Additionally, DHM induced the activation of autophagy, thereby alleviating intestinal brosis, and downregulated the PI3K/AKT/mTOR signaling pathway in vitro.Conclusions: Overall, this study demonstrated that DHM can inhibit the progression of intestinal brosis and activation of colonic broblasts by inducing autophagy through the PI3K/AKT/mTOR signaling pathway, thereby playing a preventive and therapeutic role in intestinal brosis.

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Rational surface modification of zirconium-based metal–organic framework nanomaterials for the adsorption and recovery of coloured drugs and proteins from aqueous solutions

Xia,

Hu,

Xia

et al. 2024

Colloids and Surfaces A: Physicochemical and Engineering Aspect

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An efficient cocrystallization strategy for separation of dihydromyricetin from vine tea and enhanced its antibacterial activity for food preserving application

Cited by 5 publications

References 38 publications

Thermodynamics, Solubility, and Crystallization of 1,5-Pentylenediamine Hydrochloride in Mixed Solvent Systems

Thermodynamics, Solubility, and Crystallization of 1,5-Pentylenediamine Hydrochloride in Mixed Solvent Systems

Dihydromyricetin alleviates inflammatory bowel disease associated intestinal fibrosis by inducing autophagy through the PI3K/AKT/mTOR signaling pathway

Rational surface modification of zirconium-based metal–organic framework nanomaterials for the adsorption and recovery of coloured drugs and proteins from aqueous solutions

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