An efficient and recyclable thiourea-supported copper(i) chloride catalyst for azide–alkyne cycloaddition reactions

Abstract

We have shown that an air-stable bulky thiourea-supported copper(i) chloride complex is an efficient catalyst for the synthesis of five-membered heterocycles from alkynes and azides.

Chemical Speciation of Copper in a Salt Marsh Estuary and Bioavailability to Thaumarchaeota

“…Previous measurements suggest that thiols bind copper as a Cu(I) species (Leal and van den Berg, 1998;Konigsberger et al, 2015;Barman et al, 2016). From our assumption based on the correlation between thiourea-type thiols and L 1 , an important deduction from this work is that most of the copper in these coastal waters would appear to occur in the reduced form of Cu(I).…”

Synthesis, Molecular Docking, and Preliminary Evaluation of 2‐(1,2,3‐Triazoyl)benzaldehydes As Multifunctional Agents for the Treatment of Alzheimer's Disease

“…In these described reports, the yields of 2-(1,2,3-triazoyl)benzaldehydes 5 are less than 70 % or just obtained as a byproduct. [23] In addition, Nembenna et al [24] and Khazaei et al, [25] recently in independent papers, described the use of supported thiourea-copper(I) complex in CuAAC reactions and shown a good catalytic activity for the synthesized thiourea-based catalysts. Besides, substituted thioureas could act as reductant and ligand in CuAAC reactions and a variety of 1,4-disubstituted 1,2,3-triazoles have been prepared with good to excellent yields when the CuSO 4 .5H 2 O/1-(4-methoxyphenyl)-3-phenylthiourea catalytic system in aqueous solution was used.…”

Ultrasound Promoted Fabrication of CuO‐Graphene Oxide Nanocomposite for Facile Synthesis of Fluorescent Coumarin Based 1,4‐disubsituted 1,2,3‐triazoles in Aqueous Media

“…The development of the copper‐catalyzed azide‐alkyne cycloaddition process (CuAAC) was a landmark in the creation of 1,2,3‐triazoles, and represents the epitome of “click reactions”. A large number of studies have been focused on the use of different copper salts as a homogeneous catalytic system . Non‐reusability, separation of copper from the final product, formation of metal complexes, use of expensive ligands are the limitations of this homogeneous catalysis processes since final products should be completely free from copper contamination in biological applications.…”

“…A large number of studies have been focused on the use of different copper salts as a homogeneous catalytic system. [23,27] Non-reusability, separation of copper from the final product, formation of metal complexes, use of expensive ligands are the limitations of this homogeneous catalysis processes since final products should be completely free from copper contamination in biological applications.…”