An Efficient and Rapid Synthesis of 2-amino-4-arylthiazoles Employing Microwave Irradiation in Water

Jain, Kishor S.; Bariwal, Jitender; Kathiravan, Muthu K.; Raskar, Vikas K.; Wankhede, Gajanan S.; Londhe, Nitin A.; Dighe, Satish N.

doi:10.4236/gsc.2011.12007

Cited by 7 publications

(4 citation statements)

References 18 publications

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“…Recently, new environmentally benign synthetic protocol for obtaining 2-amino-4-arylthiazoles employing microwave irradiation in water was reported. [32].…”

Section: Resultsmentioning

confidence: 99%

An environmentally Benign Synthesis of 2-Cyanomethyl-4-Phenylthiazoles under FocusedMicrowave Irradiation

Deligeorgiev¹,

Kaloyanova²,

Lesev³

et al. 2011

GSC

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“…Recently, new environmentally benign synthetic protocol for obtaining 2-amino-4-arylthiazoles employing microwave irradiation in water was reported. [32].…”

Section: Resultsmentioning

confidence: 99%

An environmentally Benign Synthesis of 2-Cyanomethyl-4-Phenylthiazoles under FocusedMicrowave Irradiation

Deligeorgiev¹,

Kaloyanova²,

Lesev³

et al. 2011

GSC

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“…It enables dramatic reduction of reaction time and hence more efficient energy metrics of the chemical process. Moreover, the microwave assisted synthesis of 2-amino-4-arylthiazoles in aqueous medium has been recently developed 11 . Therefore, it is appealing to develop the corresponding strategy for the green synthesis of the 4-Aryl-2-hydra-zinothiazole nucleus of the proposed research [12][13][14][15] .…”

Section: Fig 1: 4-aryl-2-hydarzinothiazole Derivatives As Leads For mentioning

confidence: 99%

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2018

IJPSR

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In the field of the preparation of chemotherapeutic agents with new mechanism distinct from currently approved drugs is important. However, the clinically effective approved small inhibitor molecule is still lacking. Previous reports indicated that 4-aryl-2-hydrazinothiazole derivatives provided a useful start point to develop HAT inhibitors (histone acetyltransferase). Consequently, preparation and biological evaluation of a focused library of 4-aryl-2-hydrazinothiazole based derivatives as useful as anti-cancer agents. Synthesis of 4-aryl-2-hydrazinothiazoles (1a-d), (2a-d), (3a-c), (4a-b), (5a-b), (6a-b) studied by either conventional method and free solvent microwave one-pot method, and the synthesized compounds were proved by spectroscopic methods (IR, 1 HNMR, 13 CNMR, GC-Ms, and elemental analysis). The activity against different cancer cell lines and the antimicrobial activities different organisms also studied, and all of the synthesized compounds were of high activity as an antibacterial for gram positive and gram negative; however, it showed also an antifungal activity were the most active compounds were 4a, 4b, 5b, 6a. It was found that all of the prepared thiazoles derivatives were active toward many cell lines (breast, liver, and prostate) where the more active compounds were 4a, 4b, and 6a. Molecular docking studies guided and proved the biological activities of these novel 4-aryl-2-hydrazinothiazoles.

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“…For the preparation of 2-amino-4-arylthiazoles, conventional procedures required long reaction times (6-18 h), vigorous reaction conditions, and sometimes tedious work-up, leading to low or moderate yields. Jain et al combined the advantages of microwave technology with water as an ecofriendly solvent to facilitate the synthesis of 2-amino-4-arylthiazoles [29] in excellent yields (81-97%). The reactions in water were significantly accelerated (1-20 min).…”

Section: Synthesis Of Pyrazoles and Related Compoundsmentioning

confidence: 99%