An efficient and direct synthesis of substituted 2-phenylquinoline-4-carboxamides from 3-substituted-3-hydroxyindolin-2-ones

Abstract

A simple and direct synthesis of substituted 2-phenylquinoline-4-carboxamides from 3-substituted-3hydroxyindolines in presence of ammonium acetate is described. The developed protocol also allows synthesis of the carboxamide moeity directly from isatin and acetophenone in one pot under optimized conditions. The protocol has the merits of simple reaction conditions, easy work up process and good yields of products.