An Efficient and Convenient Protocol for the Synthesis of Thiazolidin-4-Ones

A simple and environmentally benign one-pot three-component tandem synthesis of a series of novel 4-thiazolidinones has been accomplished ''on water'' by reacting aliphatic or aromatic primary amines with thioglycolic acid and a wide range of aromatic aldehydes at ambient temperature using p-dodecylbenzenesulfonic acid (DBSA) as a Brønsted acid-surfactant combined catalyst. The unique ability of the catalyst has been utilised to form emulsion droplets with organic substrates in aqueous medium whose interior core is hydrophobic enough to exclude the water molecules generated during the rate limiting dehydration step of the reaction. This protocol worked well with a variety of substrates and the desired products were obtained in fairly good yields.

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DBSA catalyzed, one-pot three-component “on water” green protocol for the synthesis of 2,3-disubstituted 4-thiazolidinones

Prasad

Nath

2012

RSC Adv.

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One-pot synthesis of 1,3-thiazolidin-4-one using ammonium persulfate as catalyst

Ebrahimi

2016

Journal of Sulfur Chemistry

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An Efficient and Convenient Protocol for the Synthesis of Thiazolidin-4-Ones

Cited by 2 publications

References 13 publications

DBSA catalyzed, one-pot three-component “on water” green protocol for the synthesis of 2,3-disubstituted 4-thiazolidinones

DBSA catalyzed, one-pot three-component “on water” green protocol for the synthesis of 2,3-disubstituted 4-thiazolidinones

One-pot synthesis of 1,3-thiazolidin-4-one using ammonium persulfate as catalyst

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