An efficacy and safety of nanofractional radiofrequency for the treatment of striae alba

Pongsrihadulchai, Napatthaorn; Chalermchai, Thep; Ophaswongse, Suwirakorn; Pongsawat, Suriya; Udompataikul, Montree

doi:10.1111/jocd.12292

Cited by 19 publications

(17 citation statements)

References 16 publications

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“…A significant improvement in all histopathological aspects (increased epidermal thickness, dermal collagen content, and elastin content) was noticed on both sides of the abdomen after our treatment. These histopathological findings are similar to those observed in previous studies utilizing bipolar RF alone 23,24 or intradermal injection of PRP alone 25 or FMR in combination with CO 2 laser 10 in the treatment of SD. Consistent with these data, high expression levels of TGF-b1 in the epidermis and dermis were observed in the treated sites.…”

Section: Discussionsupporting

confidence: 89%

Fractional microneedling radiofrequency in striae alba: Do growth factors add value?

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fawzy

Al‐Rubaiay

et al. 2020

J of Cosmetic Dermatology

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Background Various treatment modalities have been applied to treat striae alba (SA) with low satisfaction rate. Fractional microneedling radiofrequency (FMR) provides deep dermal coagulation, thereby inducing collagen synthesis and tissue tightening. The addition of platelet‐derived lyophilized growth factors may add to the effect of FMR. Objectives To evaluate and compare the efficacy and safety of FMR alone or combined with lyophilized growth factors in the treatment of SA. Methods In this left‐right comparative study, 25 patients suffering from SA on the abdomen received four sessions of FMR with lyophilized growth factors on one side and with saline (as placebo) on the other side at 4 weeks interval. Photographic and biopsy documentation of the progress of the SA was carried out before the start of the treatment and 4 weeks after the last session. Calculation of the width of SA before treatment and after 4 sessions was done by Adobe Photoshop CS6. Results There was a significant improvement in SA width after treatment in both the lyophilized growth factors (P = <.0001) and placebo sides (P = <.0001), the lyophilized growth factors being superior (P = .002). Patient satisfaction was more on the lyophilized growth factors (LGF) side (P = .034). Erythema and hyperpigmentation were less on the lyophilized growth factors side. Histopathologically, both showed improvement with no difference between LGF and placebo (epidermal thickness (P = .456), collagen content (P = .297), elastin content (P = .239)). Conclusion The combination of FMR and lyophilized growth factors improves SA outcome.

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Section: Discussionsupporting

confidence: 89%

Fractional microneedling radiofrequency in striae alba: Do growth factors add value?

Afify

fawzy

Al‐Rubaiay

et al. 2020

J of Cosmetic Dermatology

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“…Deficiency of fibrillin was reported to have a crucial role in SD histogenesis 11 . Many types of minimally invasive procedures are at hand for management of SD including; skin needling, microdermabrasion, chemical peels, mesotherapy, platelet‐rich plasma, stem cell therapy, soft tissue fillers, nonablative light‐based rejuvenation, fractional photo‐thermolysis, radiofrequency, and carboxytherapy 12‐17 …”

Section: Introductionmentioning

confidence: 99%

“…11 Many types of minimally invasive procedures are at hand for management of SD including; skin needling, microdermabrasion, chemical peels, mesotherapy, platelet-rich plasma, stem cell therapy, soft tissue fillers, nonablative light-based rejuvenation, fractional photo-thermolysis, radiofrequency, and carboxytherapy. [12][13][14][15][16][17] Carbon dioxide therapy (CDT) or carboxytherapy refers to subcutaneous or transcutaneous administration of CO 2 to produce therapeutic actions, which enhance microcirculation and tissue oxygenation. 18,19 CO 2 is an odorless, colorless gas that if injected intradermally or subcutaneously, diffuses at the skin microcirculatory level.…”

mentioning

confidence: 99%

Carboxytherapy for striae distensae: A promising modality

El‐Domyati

El‐Din

Medhat

et al. 2020

J of Cosmetic Dermatology

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Background Striae distensae (SD) is a very common skin problem. Although a lot of treatment modalities have been proposed, few of them are effective. Recently, carbon dioxide therapy (CDT) or carboxytherapy was used in many indications of cosmetic dermatology such as SD. Objectives To objectively evaluate the use and effectiveness of CDT for treatment of SD. Patients and methods Twenty patients were subjected to 8 sessions of CDT injection at 2‐week intervals using carboxy‐gun. Patients were photographed, and skin specimens were obtained from the treated area before and after 4 months of treatment. Using a computerized 3D camera, skin topography was objectively analyzed before and after treatment. Evaluation of collagen and elastic fibers by special histopathological staining, in addition to histometric analysis, was also done to evaluate treatment efficacy. Results Clinically, SD was statistically significantly improved after CDT injection compared with baseline (mean percentage of improvement of length and width, 59.8 ± 15.9; P < .05). Meanwhile, the improvement observed by the 3D camera correlated with the clinical improvement. Histometric analysis showed an increase in epidermal thickness (P < .0001) in association with re‐appearance of rete ridges following treatment. Histochemical evaluation of changes in elastic and collagen fibers after treatment showed better organization of curled and fragmented elastic fibers, which was accompanied by an increase in collagen content that became denser, arranged in bundles and parallel to the epidermis. Conclusions CDT is an effective, promising, and simple minimally invasive procedure for improving SD with few side effects and low downtime.

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“…Pongsrihadulchai et al have found statistically significant reduction in dimensions and total surface area of SD with nano-fractional RF. [66] These changes were reflected histopathologically by increase in average mean number of collagen and elastin bundles. A fractional ablative micro-plasma RF roller device (by Alma lasers, Israel) for SD was used by Mishra et al in five patients; the study concluded that there was improvement in the appearance of abdomen striae with this newer device.…”

Section: Copper-bromide Lasermentioning

confidence: 99%

Striae distensae treatment review and update

Lokhande

Mysore²

2019

Indian Dermatol Online J

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Striae distansae (SD) or stretch marks are very common, asymptomatic, skin condition frequently seen among females between 5 to 50 years of ages. It often causes cosmetic morbidity and psychological distress, particularly in women and in certain professions where physical appearances have significant importance. Of late, with the increasing emphasis on cosmetic management and awareness, patients approach dermatologists for stretch marks treatment. However, despite several advances, no fully effective treatment has emerged. Unfortunately, there is paucity of the strong evidence in the literature for the effective treatment of striae. A literature search using the terms 'striae distansae (SD or stretch marks’ was carried out in the PubMed, Google Scholar and Medline databases. Only articles related to the treatment were considered and analysed for their data. Commonly cited treatments include topical treatments like tretinoin, glycolic acid, ascorbic acid and various lasers including (like) carbon dioxide, Er:YAG, diode, Q-switched Nd:YAG, pulse dye and excimer laser. Other devices like radiofrequency, phototherapy and therapies like platelet rich plasma, chemical peeling, microdermabrasion, needling, carboxytherapy and galvanopuncture have also been used with variable success. This article reviews all currently accepted modalities and their effectiveness in the treatment of stretch marks.

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An efficacy and safety of nanofractional radiofrequency for the treatment of striae alba

Abstract: Nanofractional RF is highly effective with a good safety profile for the treatment of striae alba.

Cited by 19 publications

References 16 publications

Fractional microneedling radiofrequency in striae alba: Do growth factors add value?

Fractional microneedling radiofrequency in striae alba: Do growth factors add value?

Carboxytherapy for striae distensae: A promising modality

Striae distensae treatment review and update

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