An effective therapy for nonunions-Low-intensity ultrasound

Nolte, P A; Albers, G. H. R.; Janssen, Ignace M. C.; Krans, A van der

doi:10.1097/00005131-199905000-00073

Cited by 5 publications

(5 citation statements)

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“…Although the same cellular processes are present in bone healing after osteotomies and fracture healing, a few studies demonstrated that LIPUS enhanced bone healing at the osteotomy site after osteotomy surgeries. 18 - 21 Regarding HTO, Tsumaki et al 19 suggested that LIPUS accelerated callus maturation during the consolidation phase after open-wedge HTO by hemicallotasis. They reported that the external fixators were removed at a mean time of one week earlier from the ultrasound treated limbs than from the control limbs.…”

Section: Discussionmentioning

confidence: 99%

“…They reported that the external fixators were removed at a mean time of one week earlier from the ultrasound treated limbs than from the control limbs. Nolte et al 18 reported that LIPUS enhances bone healing in closed wedge HTO and reduces the occurrence of delayed union or nonunion. However, there are few reports that evaluated whether LIPUS promotes bone healing after modern OWHTO with a locking plate.…”

Section: Discussionmentioning

confidence: 99%

“… 16 , 17 Moreover, several studies demonstrated that LIPUS enhanced bone healing after osteotomy surgeries. 18 - 21 Urita et al 20 reported that LIPUS shortened the time to cortical union by 27%, and to endosteal union by 18% after forearm bone shortening osteotomies. Furthermore, Tsumaki et al 19 suggested that LIPUS accelerated callus maturation during the consolidation phase after OWHTO by hemicallotasis.…”

Section: Introductionmentioning

confidence: 99%

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Low-intensity pulsed ultrasound does not promote bone healing and functional recovery after open wedge high tibial osteotomy

et al. 2022

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Aims To evaluate whether low-intensity pulsed ultrasound (LIPUS) accelerates bone healing at osteotomy sites and promotes functional recovery after open-wedge high tibial osteotomy (OWHTO). Methods Overall, 90 patients who underwent OWHTO without bone grafting were enrolled in this nonrandomized retrospective study, and 45 patients treated with LIPUS were compared with 45 patients without LIPUS treatment in terms of bone healing and functional recovery postoperatively. Clinical evaluations, including the pain visual analogue scale (VAS) and Japanese Orthopaedic Association (JOA) score, were performed preoperatively as well as six weeks and three, six, and 12 months postoperatively. The progression rate of gap filling was evaluated using anteroposterior radiographs at six weeks and three, six, and 12 months postoperatively. Results The pain VAS and JOA scores significantly improved after OWHTO in both groups. Although the LIPUS group had better pain scores at six weeks and three months postoperatively, there were no significant differences in JOA score between the groups. The lateral hinge united at six weeks postoperatively in 34 (75.6%) knees in the control group and in 33 (73.3%) knees in the LIPUS group. The progression rates of gap filling in the LIPUS group were 8.0%, 15.0%, 27.2%, and 46.0% at six weeks and three, six, and 12 months postoperatively, respectively, whereas in the control group at the same time points they were 7.7%, 15.2%, 26.3%, and 44.0%, respectively. There were no significant differences in the progression rate of gap filling between the groups. Conclusion The present study demonstrated that LIPUS did not promote bone healing and functional recovery after OWHTO with a locking plate. The routine use of LIPUS after OWHTO was not recommended from the results of our study. Cite this article: Bone Jt Open 2022;3(11):885–893.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Low-intensity pulsed ultrasound does not promote bone healing and functional recovery after open wedge high tibial osteotomy

et al. 2022

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“…Nolte et al reported that LIPUS treatment for established nonunions had no side effects. 58 Ultrasound helps to achieve the bone union similar to surgical means without causing any complications to patients, which is particularly crucial to the elderly patients with low healing ability. 37 It has been discovered that the efficiency of bone union using LIPUS treatment was closely related to the time duration between the most recent surgery and ultrasound treatment and it should be less than 3 months.…”

Section: Clinical Evidences On Fracture Healingmentioning

confidence: 99%

Low‐Intensity Pulsed Ultrasound Stimulation for Bone Fractures Healing

Palanisamy

Alam

et al. 2021

J of Ultrasound Medicine

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Low‐intensity pulsed ultrasound (LIPUS) is a developing technology, which has been proven to improve fracture healing process with minimal thermal effects. This noninvasive treatment accelerates bone formation through various molecular, biological, and biomechanical interactions with tissues and cells. Although LIPUS treatment has shown beneficial effects on different bone fracture locations, only very few studies have examined its effects on deeper bones. This study provides an overview on therapeutic ultrasound for fractured bones, possible mechanisms of action, clinical evidences, current limitations, and its future prospects.

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“…LIPUS is traditionally applied to the skin above the fracture and provides a transdermal energy impulse that, for reasons that are not well understood, appears to result in the accelerated repair of simple fractures. The clinical data supporting this finding is not abundant and is to a certain degree, contradictory [2][3][4][5][6][7][8][9][10][11][12][13][14][15][16][17][18]. The data is, however, compelling enough to have motivated a considerable body of research into how LIPUS impacts osteoblasts, osteocytes, and other cells and cellular processes implicated in the normal sequence of fracture repair.…”

Section: Introductionmentioning

confidence: 99%

A Critical Assessment of the Clinical Efficacy and Cellular Response to Low Intensity Pulsed Ultrasound for Fracture Repair

Laurencin

Khan

2010

Advances in Science and Technology

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Fracture repair continues to be widely investigated, both within the clinical realm and at the fundamental research level. Clinical application of low intensity pulsed ultrasound (LIPUS) has shown great promise as an effective, minimally invasive treatment for accelerating fracture repair and has warranted further investigation into the cellular manifestation of applied ultrasound. Toward this end much has been learned about the response of osteoblasts to LIPUS stimulation. In vitro and in vivo evaluation of cellular response to LIPUS have revealed an increase in proliferation, protein synthesis, collagen synthesis, membrane permeability, integrin expression, and increased cytosolic calcium, to name a few, further clarifying its utility and overall impact on cellular behavior. Considerable effects of LIPUS on the cells of musculoskeletal soft tissue have been reported as well. The growing body of research in this area suggests that LIPUS may be a powerful tool in the development of novel approaches to musculoskeletal repair and regeneration. Regenerative engineering-based approaches to musculoskeletal healing and regeneration that incorporate polymeric scaffolds and stem cells may be combined with LIPUS to move beyond bone repair to large scale multicomponent tissue repair.

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An effective therapy for nonunions-Low-intensity ultrasound

Cited by 5 publications

References 0 publications

Low-intensity pulsed ultrasound does not promote bone healing and functional recovery after open wedge high tibial osteotomy

Low-intensity pulsed ultrasound does not promote bone healing and functional recovery after open wedge high tibial osteotomy

Low‐Intensity Pulsed Ultrasound Stimulation for Bone Fractures Healing

A Critical Assessment of the Clinical Efficacy and Cellular Response to Low Intensity Pulsed Ultrasound for Fracture Repair

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