An effective sample preparation approach for screening the anticancer compound piceatannol using HPLC coupled with UV and fluorescence detection

Lin, Lilian Tsai-Wei; Lien, Ching-Yi; Cheng, Ya-Chin; Ku, Kuo-Lung

doi:10.1016/j.jchromb.2007.03.007

Cited by 40 publications

(22 citation statements)

References 38 publications

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“…On exposure to UV, the trans form is changed into the cis form, so the isolation is generally performed in dark conditions. 7 Several studies conducted under various conditions showed that trans-resveratrol remained stable for several months (except in high pH buffers) when completely protected from light. Now there are methods to assay both the isomers.…”

Section: Structure and Chemistry Of Resveratrolmentioning

confidence: 99%

Resveratrol: A multitargeted agent for age-associated chronic diseases

Harikumar¹,

Aggarwal²

2008

Cell Cycle

481

339

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Extensive research within the last decade has revealed that most chronic illnesses such as cancer, cardiovascular and pulmonary diseases, neurological diseases, diabetes, and autoimmune diseases exhibit dysregulation of multiple cell signaling pathways that have been linked to inflammation. Thus mono-targeted therapies developed for the last two decades for these diseases have proven to be unsafe, ineffective and expensive. Although fruits and vegetables are regarded to have therapeutic potential against chronic illnesses, neither their active component nor the mechanism of action is well understood. Resveratrol (trans-3, 5, 4'-trihydroxystilbene), a component of grapes, berries, peanuts and other traditional medicines, is one such polyphenol that has been shown to mediate its effects through modulation of many different pathways. This stilbene has been shown to bind to numerous cell-signaling molecules such as multi drug resistance protein, topoisomerase II, aromatase, DNA polymerase, estrogen receptors, tubulin and F1-ATPase. Resveratrol has also been shown to activate various transcription factor (e.g., NFκB, STAT3, HIF-1α, β-catenin and PPAR-γ), suppress the expression of antiapoptotic gene products (e.g., Bcl-2, Bcl-X L , XIAP and survivin), inhibit protein kinases (e.g., src, PI3K, JNK and AKT), induce antioxidant enzymes (e.g., catalase, superoxide dismutase and hemoxygenase-1), suppress the expression of inflammatory biomarkers (e.g., TNF, COX-2, iNOS and CRP), inhibit the expression of angiogenic and metastatic gene products (e.g., MMPs, VEGF, cathepsin D and ICAM-1), and modulate cell cycle regulatory genes (e.g., p53, Rb, PTEN, cyclins and CDKs). Numerous animal studies have demonstrated that this polyphenol holds promise against numerous age-associated diseases including cancer, diabetes, Alzheimer, cardiovascular and pulmonary diseases. In view of these studies, resveratrol's prospects for use in the clinics are rapidly accelerating. Efforts are also underway to improve its activity in vivo through structural modification and reformulation. Our review describes various targets of resveratrol and their therapeutic potential.

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Section: Structure and Chemistry Of Resveratrolmentioning

confidence: 99%

Resveratrol: A multitargeted agent for age-associated chronic diseases

Harikumar¹,

Aggarwal²

2008

Cell Cycle

481

339

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“…Trans isomeric form is sterically more stable in comparison to cis isomeric form [25]. The presence of piceatannol has been confirmed in different fruits and plants such as Vaccinium berries, Vitis amurensi, grapes, Arachis hypogaea, Polygonum cuspidatum [26][27][28][29]. The concentration of this compound was found to vary in different sources and it was characterized by different analytical techniques.…”

Section: Piceatannolmentioning

confidence: 99%

Piceatannol: A Potential Futuristic Natural Stilbene as Fetal Haemoglobin Inducer

Kukreja

Tandon

Mishra

et al. 2013

JCDR

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“…Trans-Resveratrol or Res (trans-3,5,4'-trihydroxystilbene) ( Fig.5) (Lin 2007) and its many derivatives (pterostilbene, piceatannol) are naturally occurring phytoalexins; a class of antibiotic compounds, produced in a select number of plant species as part of the plant's defense system (Bolivar, 2007).The terminal enzyme in the production of resveratrol is resveratrol synthase, which condenses p-coumaroyl-coenzyme A and three malonylcoenzyme A molecules to form resveratrol (Bolivar, 2007).This enzyme is highly regulated by elicitors and general plant defense compounds in an effort to protect the plant. Resveratrol exist as both the trans-and cis-isomers but the most active for is the trans one.…”

Section: Structurementioning

confidence: 99%

“…Piceatannol is more efficient inducer of apoptosis (Lin, 2007). Other reports, suggested that both piceatannol and resveratrol are able to induce apoptosis in many cancer cell lines, but to different extent (Lin 2007). Lin et al reported that piceatannol is more effective in cancer prevention and could be an anticancer compound while resveratrol is a chemoprotective one.…”

Section: Resveratrol and Effectsmentioning

confidence: 99%

“…Lin et al reported that piceatannol is more effective in cancer prevention and could be an anticancer compound while resveratrol is a chemoprotective one. In fact, resveratrol and piceatannol become promising natural compounds in cancer treatments (Lin, 2007), they blocks the carcinogenesis stages of initiation, promotion and progression (Lu, 2009). …”

Section: Resveratrol and Effectsmentioning

confidence: 99%

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