An effective method for improving outcomes in patients with a fertilization defect

Abstract

The effect of artificial oocyte activation (AOA) with a calcium ionophore on intracytoplasmic morphologically selected sperm injection (IMSI) was examined in patients with histories of repeated failed implantation attempts. Four singleton pregnancies and one twin pregnancy were obtained after embryos transfer (5/14, 35.7%). Therefore, AOA combined with IMSI can be considered an option for cycles with a fertilization defect and recurrent implantation failures.

Aide à l’activation ovocytaire

“…de PLCζ permet de rétablir les oscillations calciques dans les ovocytes murins injectés avec les spermatozoïdes de patients infertiles qui ne comportent pas de PLCζ [12]. Récemment, un second candidat a été proposé par Aarabi et al [13].…”