An effective Biginelli-type synthesis of 1-methoxy-3,4-dihydropyrimidin-2(1H)-ones

Колосов, Максим А.; Кулык, Олеся Г.; Al‐Ogaili, Muataz J. K.; Orlov, V. D.

doi:10.1016/j.tetlet.2015.06.041

Cited by 10 publications

(1 citation statement)

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“…CeCl 3 ‐catalyzed the synthesis of 420 , which are monastrol (a kinesin Eg5 inhibitor) analogues and potential anticancer agents [184]. Other methods such as TMSCl/DMF 421 procedure [185], solid‐phase protocol 422 [186], NaHSO 4 ‐catalyzed [187], Yb(OTf) 3 ‐catalyzed or FeCl 3 ‐catalyzed 423 synthesis were also developed (Scheme 105) [188].…”

Section: Six‐membered Heterocycles With Multiple Heteroatomsmentioning

confidence: 99%

The applications of β‐keto amides for heterocycle synthesis

2022

Journal of Heterocyclic Chem

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β-Keto amides have multiple nucleophilic and electrophilic reaction sites within their molecular structures, which make them excellent building blocks for the construction of various heterocyclic compounds. In this Review, we summarized the applications of structurally diversified β-keto amides for the synthesis of (1) Five-membered heterocycles including furans, thiophenes, pyrroles, indoles, pyrazoles, triazoles, and their derivatives; (2) six-membered nitrogen-and oxygen-containing heterocycles such as pyridones, dihydropyridines, pyridines, quinolones, quinolines, pyranones and the like; (3) various lactams and some aza-aliphatic rings. The focus is on the multicomponent reactions which take advantage of the unique versatile reactivities of β-keto amides.

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