The unzipping analysis, based on the alternate shear deformation process of two intersecting shear planes at a crack tip, is extended to study fatigue crack growth in a two-phase martensitic-ferritic steel. The unzipping crack increment Aauz is directly related to AK and AJ in the case of small scale yielding. It is preferrable to use Aa~ is directly related to AK and AJ in the case of small scale yielding. It is preferable to use Aa~ as a physical parameter to correlate with the growth rates of micro-cracks and fatigue cracks in a multi-phase material. In the case of micro-cracks, AK is often not applicable because of extensive plastic deformation; and in the case of multi-phase material, neither AK nor AJ is applicable because of material inhomogeneity. The effective AK, AKin, is defined in terms of Aa~. The relations between the endurance limit of a two-phase steel and crack nucleus size, ferrite layer thickness, the constraint by the strong martensite on crack tip deformation in the ferrite domain, and AKth's of the martensite and ferrite are analyzed.