An effect of cytoprotective therapy on stress resistance and compensatory abilities of patients with chronic cerebral ischemia

Антипенко, Е. А.; Derugina, A. V.; Густов, А. В.

doi:10.17116/jnevro201511511274-78

Cited by 4 publications

(5 citation statements)

References 4 publications

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“…(6) Cytoflavin is a complex preparation, the composition of which comprises the following components: succinate acid, riboflavin, riboxinum, and nicotinamide. (20) Earlier it was shown that this group of preparations decreases the intensity of LPO both in blood plasma and in cell membranes. (21) It is very important to note that mexicor and cytoflavin promoted a decrease in the LMMWS content.…”

Section: Discussionmentioning

confidence: 94%

Endogenous Intoxication and the Role of Antioxidants in Motion Activity Correction with Traumatic Brain Injury in Rat Model

Polozova¹,

Bojarinov²,

Ivashchenko³

et al. 2019

IJBM

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The aim of this study was to assess the effectiveness of cytoflavin and mexicor in the posttraumatic period of traumatic brain injury (TBI). Materials and Methods:The experiments were carried out on 60 white non pedigree female rats weighing 180-200 g, with 15 rats in each series. TBI was modeled by a free-falling weight drop of 100 g from a height of 80 cm on the parietal-occipital area of the head. Blood samples were taken from the sublingual vein in an amount of 2.0 ml on Days 1, 3, 7, and 12 after the alteration. After TBI, in Group 1, 15 rats received an intraperitoneal injection of 2-ethyl-6-methyl-3-hydroxypyridine succinate (mexicor) for 10 days in a daily dose of 8.0 mg/kg. In Group 2, 15 rats received an intraperitoneal injection of cytoflavin for 10 days in a daily dose of 0.2 ml/kg. The activity of lipid peroxidation and antioxidant protection system in the blood plasma was determined by a biochemicoluminescence method. Analysis of animal motion activity included the determination of the ability to balance and to stay at the wooden bar, time spent for moving on the bar from the bright light source to the darkroom, and paw slip frequency.Results: Mexicor and cytoflavin decreased the level of oxidative processes in rat model with TBI and the development of secondary brain injury. The positive dynamics in restoring pro-and antioxidant system balance was combined with positive changes in motor function.

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Section: Discussionmentioning

confidence: 94%

Endogenous Intoxication and the Role of Antioxidants in Motion Activity Correction with Traumatic Brain Injury in Rat Model

Polozova¹,

Bojarinov²,

Ivashchenko³

et al. 2019

IJBM

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“…Скрининг текстов и цифровых значений публикаций проводили в соответствии с поставленной целью методики выполнения, корректности статистической обработки, связи выводов со статистически подтвержденными доказательствами, приведенными в статье, или при возможности их вычисления и проверки читателем. По результату скрининга была отобрана 21 публикация [19][20][21][24][25][26][27][28][29][30][31][32][33][34][35][36][37][38][39][40][41], соответствующая общепринятым критериям включения [42], содержащая частотные характеристики положительных и отрицательных исходов вмешательства в группах сравнения. Метаанализ проводили поэтапно: 1) поиск опубликованных работ, содержащих данные по проблеме; 2) обоснование принципов отбора публикаций для включения в систематический анализ; 3) перевод опубликованных данных в унифицированные показатели клинической эффективности; 4) сравнительный анализ унифицированных показателей методами описательной статистики и метаанализа в условиях гетерогенности показателей-откликов; 5) определение изменчивости (устойчивость) клинической эффективности с применением статистических моделей фиксированных и случайных эффектов.…”

Section: материал и методыunclassified

“…Совокупность опубликованных данных по характеристикам медицинских вмешательств с применением цитофлавина [19][20][21][24][25][26][27][28][29][30][31][32][33][34][35][36][37][38][39][40][41] сочетала разнообразие диагнозов и схем фармакотерапии. Исследования проводились в разных клиниках, независимо друг от друга, конфликт интересов отсутствовал.…”

Section: результаты и обсуждениеunclassified

“…Этому противостоял позитивный объединяющий фактор, который заключался в широком спектре патологических состояний, поддающихся коррекции цитофлавином. Это свидетельствовало об универсальности и неспецифичности его применения на фоне курсового применения цитофлавина в основной группе и доказанной связи основных звеньев патогенеза с гипоксией и митохондриальной дисфункцией [19][20][21][24][25][26][27][28][29][30][31][32][33][34][35][36][37][38][39][40][41].…”

Section: результаты и обсуждениеunclassified

“…Введение в организм ЯК или кофакторов окислительного фосфорилирования способствует повышению адаптационного резерва организма, повышает его устойчивость к стрессам, ускоряет и облегчает выход из патологических состояний [2,3,[5][6][7]. Комбинации ЯК с глютаминовой или яблочной кислотами оказывают мощный энергомодулирующий эффект [19][20][21][22][23].…”

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Meta-analytic assessment of parenteral cytoflavin effectiveness in different neurologic disorders

Mazin¹,

Sheshunov²,

Mazina³

2017

Z. nevrol. psikhiatr. im. S.S. Korsakova

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An analysis of formalized efficacy indicators (increase in the absolute and relative value, odds ratio (OR) etc.) has demonstrated the advantages of cytoflavin. Group combination has increased the statistical power of the meta-analysis. Two models with fixed (Mantel-Haenszel amendment) and random effects were used. All the estimation protocols in different clinical groups of patients with neurologic diseases provided similar results and confirmed the stability of calculated values irrespective of heterogeneity of data arrays. OR of positive outcomes in neuropathologies treated with cytoflavin was 3,02 with χ2 heterogeneity 427,3 and p = 0,000…, I2= 85,7% (82%; 88%).

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Electrokinetic, oxidative and aggregation properties of red blood cells in the postoperative period following kidney transplantation

Дерюгина

Abaeva

Романов

et al. 2020

RJTAO

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Objective: to study the electrokinetic and aggregation properties, as well as the pro-oxidant and antioxidant processes in red blood cells following kidney transplantation in donors and in recipients in the postoperative period. Materials and methods. Blood from 12 recipients and 5 kidney donors over time – before transplantation, as well as at week 1, months 1, 2, 7, 10 and 12 after surgery, as well as from 8 healthy volunteers who formed the control group. We used microelectrophoresis to measure the electrophoretic mobility of red blood cells, characterizing the electrokinetic properties of cells. Aggregation was calculated microscopically by counting unaggregated red blood cells. Malondialdehyde concentration was measured spectrophotometrically at its absorbance maximum at 530 nm by reaction with thiobarbituric acid. Catalase activity was analyzed by reducing hydrogen peroxide in the sample spectrophotometrically at 240 nm wavelength. The obtained values were compared using the Mann–Whitney U test. Results. Decreased electrophoretic mobility of red blood cells within 2 months after transplantation was associated with increased malondialdehyde concentration and erythrocyte aggregation, decreased catalase activity in kidney recipients, followed by restoration of indicators to the control values. Electrophoretic mobility of red blood cells decreased, while malondialdehyde concentrations increased in donors after surgery. However, the increase was less pronounced than in recipients. The changes indicate that the postoperative period causes changes at the cellular level both in donors and in recipients. This is manifested by decreased stability of erythrocyte membrane structure, which is largely determined by lipid peroxidation processes. At the systemic level, a change in the electrophoretic mobility of red blood cells indicates a stress reaction before and after kidney transplantation in recipients within 2 months after surgery, and in donors in 1–2 months in the postoperative period with gradual increase in the body’s resistance. Conclusion. Kidney transplantation is manifested at the cellular and systemic levels. At the cellular level, there is decreased stability of the membrane structure, which is largely determined by lipid peroxidation processes. At the systemic level, a change in the electrophoretic mobility of red blood cells indicates a stress reaction with gradual increase in the body’s resistance. The data obtained demonstrate changes in the functional properties of red blood cells both in kidney transplant recipients and in donors. These changes need to be taken into account when carrying out therapeutic measures.

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An effect of cytoprotective therapy on stress resistance and compensatory abilities of patients with chronic cerebral ischemia

Cited by 4 publications

References 4 publications

Endogenous Intoxication and the Role of Antioxidants in Motion Activity Correction with Traumatic Brain Injury in Rat Model

Endogenous Intoxication and the Role of Antioxidants in Motion Activity Correction with Traumatic Brain Injury in Rat Model

Meta-analytic assessment of parenteral cytoflavin effectiveness in different neurologic disorders

Electrokinetic, oxidative and aggregation properties of red blood cells in the postoperative period following kidney transplantation

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