An economic analysis of rotavirus vaccination in Italy

Group A rotavirus genotypes circulating prior to implementation of a National Immunization Program in Estonia

“…Similarly to the whole study, the most prevailing strain in the nosocomial infections was G2P [4] (50%), only one mixed infection occurred and 38.8% of isolated RVA were partially untypeable. In contrast to the whole population, the prevalence of G4P [8] among hospital-acquired infections was 5.6%.…”

“…5 Yet, as it has been stated by several authors, only long-term surveillances 7,8,10,27 and phylogenetic analysis of G2P [4] samples from vaccinated and unvaccinated children 28 can determine the true effect of vaccination on G2P [4] strain.…”

“…The sentiment is illustrated by the fact that many cost-effectiveness analyses conducted in western countries prior to the decision do not take into account the molecular epidemiology of RVGE. [4][5][6] A cost-effectiveness study is currently being performed by the Department of Public Health of the University of Tartu to answer the question about the introduction of the vaccines into the national immunization program of Estonia. As up to now only some European countries (Finland, Greece) have found the vaccination to be economically beneficial 5,31 and others (France, Italy, the Netherlands) have stated that the prices of the vaccines should be reduced in order to genotype combinations were G2P [4] [8] dominated and the level of partially or fully untypeable strains remained low (< 14%).…”

“…The majority of cases (65%) occurred in infants aged 7 to 24 mo and were of moderate severity [mean clark score 12.1 (sD 3.2)]. The prevailing strain was G2p [4] RVA vaccines is less clear. G1P [8] still remains the most dominant, accounting for 61.6% of strains in the Australian states utilizing RotaTeq.…”

“…"Common" RVA strains (G1P [8], G2P [4], G3P [8], G4P [8] and G9P [8]) accounted for 57.3% of cases ( "Uncommon" human strains, arising from the reassortment of genetic material of "common" human strains, occurred in 3.2% of samples. Other combinations, which likely result from reassortment between animal and human strains, accounted for 1.6%.…”