Wetlands of the south of Europe and north Africa extend from Bulgaria to the Iberian peninsula, and from Tunisia to Morocco. The three main environmental factors explaining the distribution of the wetlands are: climate, topography and geology, and tides. The principal geomorphological formations containing wetlands are described in detail and numerous examples are given. They are: river deltas, coastal lagoons, riverine floodplains, inland freshwater lakes, man-made reservoirs, athalassic salt basins, intertidal systems, permanent river channels, and seasonally-flooded river channels. Many inventories and classifications of wetlands of the region have been carried out, but few of them are comparable. A new classification is proposed for the whole study area. The factors determining the ecological characteristics of the emergent and submerged vegetation of Mediterranean wetlands are identified and their impacts on the composition of the vegetation are analyzed in detail. Six vegetation categories have been determined: halophytic vegetation, emergent reedswamp communities, riverine forests, dwarf rush communities, and submerged and floating vegetation of freshwater habitats. Invertebrates, fish, birds, and mammals occurring in Mediterranean wetlands are listed and the factors responsible for their presence or absence are analyzed. As a general rule, birds are very well known, but information on invertebrates, fish, and mammals is still poor. The usage of and conservation problems of Mediterranean wetlands show that most of them are overexploited and degraded, and few are protected. Many organisms depending on these wetlands are nowadays threatened with extinction. Although the distribution and size of the Mediterranean wetlands is well known, the functioning of the ecosystems in the Mediterranean region remains poorly understood. This is a major handicap at the moment, when ways of better managing or even restoring certain Mediterranean wetlands are being talked of.