An ecological implication of glandular trichome-sequestered artemisinin: as a sink of biotic/abiotic stress-triggered singlet oxygen

Abstract

Artemisinin is accumulated in wormwood (Artemisia annua) with uncertain ecological implications. Here, we suggest that artemisinin is generated in response to biotic/abiotic stress, during which dihydroartemisinic acid, a direct artemisinin precursor, quenches singlet oxygen ( 1 O2), one kind of reactive oxygen species. Evidence supporting artemisinin as a sink of 1 O2 emerges from that volatile isoprenoids protect plants from biotic/abiotic stress; biotic/abiotic stress induces artemisinin biosynthesis; and stress signaling pathways are involved in the biosynthesis of volatile isoprenoids among plants as well as the biosynthesis of artemisinin in A. annua. In this review, we address the ecological implication of glandular trichome-sequestered artemisinin as a sink sink of biotic/abiotic stress-triggered 1 O2, and also summarize the cumulating data on the transcriptomic and metabolic profiling of stress-enhanced artemisinin production upon eliciting 1 O2 omission from chloroplasts and initiating retrograde 1 O2 signaling from chloroplasts to nuclei.

Identification of the Volatile Compounds and Observation of the Glandular Trichomes in Opisthopappus taihangensis and Four Species of Chrysanthemum

“…However, among the eight different types of Solanaceae species, only four types (types II, III, V, and VIII) are secretory GTs [38]. In Asteraceae plants, Helianthus annuus [42], Pyrethrum cinerariaefolium [36], and A. annua [43] also have GTs with a secretion function. The GTs of Tussilago farfara have an oblong head and a long stalk cell and can produce phenols and terpenoids [44].…”