An ecofriendly procedure to extract isoflavones from soybean seeds

Lante, Anna; Barion, Giuseppe; Zannoni, Stefania; Pastore, Maria Rita; Tinello, Federica; Cortivo, Cristian Dal; Vamerali, Teofilo; Mosca, Giuliano

doi:10.1016/j.jclepro.2017.09.218

Cited by 15 publications

(5 citation statements)

References 41 publications

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“…Conventional extraction methods are based on the use of chemical solvents and sample heating to maximize the solubility of the active principles and speed up mass transfer. The extraction yield depends on several factors, including the type, concentration and amount of solvent, its residence time and temperature [ 30 ]. Different processing times (10 and 30 min) and two ethanol concentrations (50% and 70%) were employed for flower heads extraction using UAE (temperature 40 °C).…”

Section: Resultsmentioning

confidence: 99%

Novel Extraction Method Using Excipients to Enhance Yield of Genistein and Daidzein in Trifolium pratensis L.

2021

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Isoflavones can be found in different chemical forms, but the health beneficial effects mainly appear in their free forms—aglycones. Their yield in red clover (Trifolium pratensis L.) extracts differs due to different extraction and hydrolysis methodologies. The main aim of this study was to obtain the highest yields of daidzein and genistein from red clover blossoms through the various extraction and hydrolysis methods and to increase their quantities using additional excipients. Extracts were obtained by ultrasound-assisted, heat-reflux and maceration methods combining them with acidic, alkaline, and thermal hydrolysis. Using ultrasound-assisted extraction with optimal conditions and heat-reflux method highest yields of isoflavones were obtained in UTE510 (393.23 ± 19.66 µg/g daidzein and 171.57 ± 8.58 µg/g genistein); UTE530 (415.07 ± 20.75 µg/g daidzein and 150.57 ± 7.53 µg/g genistein) and HNE5 (432.30 ± 21.61 µg/g daidzein and 154.50 ± 7.72 µg/g genistein) samples. These conditions were used with excipients: magnesium aluminometasilicate, croscarmellose sodium, sodium carboxymethyl starch and vinylpyrrolidone-vinyl acetate copolymer. This is the first study reporting the ability of the vinylpyrrolidone-vinyl acetate copolymer to promote solubilization and availability of active compounds from a herbal extract, resulting in enhanced isoflavones yield. The results of the present study showing increased solubility and availability provided by the vinylpyrrolidone-vinyl acetate copolymer suggest that this preparation could in principle also reduce variability due to limited water solubility of isoflavones.

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Section: Resultsmentioning

confidence: 99%

Novel Extraction Method Using Excipients to Enhance Yield of Genistein and Daidzein in Trifolium pratensis L.

2021

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“…Alternative isoflavone extraction processes have been proposed, such as supercritical fluid extraction and ultrasonic‐assisted methods 33–36 . More recently, an eco‐friendly isoflavone extraction method has been developed, which uses water as the extracting solvent in conjunction with conventional agitation and separation techniques 33–37 . However, side‐by‐side comparisons of multiple processing pathways still remain challenging as simulating each extraction and purification pathway can be time‐consuming and lead to suboptimal solutions.…”

Section: Introductionmentioning

confidence: 99%

“…[33][34][35][36] More recently, an eco-friendly isoflavone extraction method has been developed, which uses water as the extracting solvent in conjunction with conventional agitation and separation techniques. [33][34][35][36][37] However, side-by-side comparisons of multiple processing pathways still remain challenging as simulating each extraction and purification pathway can be time-consuming and lead to suboptimal solutions. Alternatively, a simultaneous analysis methodology will provide a comparative assessment of the different extraction pathways, supporting faster decision-making regarding process feasibility, technology commercialization and economic viability.…”

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confidence: 99%

Evaluation of isoflavone extraction options at commercial scale

Chea

Lehr

Stanzione

et al. 2022

Biofuels Bioprod Bioref

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Resource sustainability concerns keep increasing owing to the continuous use of natural materials without reclamation. Efforts are ongoing to find sustainable feedstocks for naturally derived products with competitive economics and properties. However, there is no established methodology for commercializing the extraction of chemicals from renewable sources. This work examined soybeans as a potential bio‐based feedstock to generate isoflavones at a commercial scale. The isoflavone content in soybeans has proven beneficial in the nutraceuticals industry for its anti‐inflammatory and cancer‐inhibition properties and in the materials sector owing to their inherent chemical functionality and thermal resistance. Currently, isoflavone extraction is only optimized at lab scale. Thus, we present a superstructure‐based framework to screen isoflavone extraction methods and assess their viability at a commercial scale. This allows the simultaneous comparison of alternative technologies using mixed‐integer nonlinear programming optimization to determine the most economical pathway. Internal material recovery greatly enhances the viability at a commercial scale by reducing the annual operating cost and environmental footprint. Therefore, this work presents a powerful tool for systematically comparing extraction pathways and assessing their commercial feasibility. The successful implementation of commercial‐scale extraction of isoflavone has tremendous potential for generating additional revenue for US soy farmers. Isoflavones can produce bio‐based polymers and composites and are used in products such as dietary supplements, cosmetics and nutraceuticals. Similar works can be applied to extract other natural materials from renewable feedstocks and increase the production of bio‐based products. © 2022 Society of Chemical Industry and John Wiley & Sons, Ltd.

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“…Water and ethanol and a combination of the two were the most popular solvents for extracting bioactive chemicals for food applications (Mihaylova and Lante, 2019). Lante et al (2018) utilzed water as solvent for extraction of soy isoflavones. The various extraction parameters like solvent, temperature, time, particle size, and solid-to-liquid ratio impact extraction (Dent et al 2013).…”

Section: Introductionmentioning

confidence: 99%

Comparative assessment, optimization and characterization of bioactive constituents from Amaranthus species: An indigenous lesser-known vegetables of India

Chikane

Patil

Bhushette

et al. 2021

FSAB

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Amaranthus Tricolor L. (red amaranth) and Amaranthus Viridis (Green amaranth) are Amaranthaceae members, widely cultivated in Asia and consumed as a leafy vegetable in many parts of the world. This study deal with the nutritional and functional, and biochemical characterization of A. Tricolor and A. viridis . Single-factor experiments and Box Behnken Design (BBD) were used to optimize the extraction process for the phenolic compound from A. Tricolor and A. viridis . The BBD shows that 11.87mg/g phenolic extract of A. Tricolor produced at the optimal condition of solid to water ratio (1:15), temperature (30°C), and time (15 min). Similarly, A. viridis isolated 18.36mg/g of phenolics at optimal condition solid to liquid ratio (1:30), temperature (30°C), and time (60 min). The radical scavenging activity of A. Tricolor and A. viridis shows 63.52% and 19.27%, respectively, by the DPPH method. The bioactive compounds 3,4,5-Trihydroxystilbene and caffeic acid were found in A. Tricolor, and in A. viridis it showed caffeic acid, which was identified using LC-MS/MS.

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An ecofriendly procedure to extract isoflavones from soybean seeds

Cited by 15 publications

References 41 publications

Novel Extraction Method Using Excipients to Enhance Yield of Genistein and Daidzein in Trifolium pratensis L.

Novel Extraction Method Using Excipients to Enhance Yield of Genistein and Daidzein in Trifolium pratensis L.

Evaluation of isoflavone extraction options at commercial scale

Comparative assessment, optimization and characterization of bioactive constituents from Amaranthus species: An indigenous lesser-known vegetables of India

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