An easy Z-score imaging system for discrimination between very early Alzheimer??s disease and controls using brain perfusion SPECT in a multicentre study

tau protein and the absence of 14-3-3 protein, as well as decreased concentrations of neuron-specific enolase, S100 protein, and prostaglandin E 2 . All patients presented with unique MRI features. Brain biopsy showed severe spongiform morphology, but comparatively preserved neurons and mild astrocytic gliosis. Accumulations of PrP Sc were not detected using the 3F4 antibody, and microglial activation was subtle. SPECT revealed hypoperfusion throughout both hemispheres. MRS revealed a reduced N-acetyl aspartate/ creatine ratio. Conclusion: Results from this study suggested that increased DWI signals could reflect severe spongiform changes in CJD180 patients.

Section: Biochemical Analysis Of Csf Samplesmentioning

confidence: 99%

Familial Creutzfeldt-Jakob Disease with a V180I Mutation: Comparative Analysis with Pathological Findings and Diffusion-Weighted Images

Mutsukura¹,

Satoh²,

Shirabe

et al. 2009

“…We applied the easy Z score imaging system (eZIS) for qualitative analysis of brain perfusion SPECT [7,8] . Two examiners, who were blinded to the diagnosis of DLB, assessed the presence or absence of occipital hypoperfusion.…”

Section: Subjectsmentioning

confidence: 99%

Comparison of the Usefulness of Brain Perfusion SPECT and MIBG Myocardial Scintigraphy for the Diagnosis of Dementia with Lewy Bodies

Tateno

Kobayashi²,

Shirasaka³

et al. 2008

Background: Supportive features in the diagnostic criteria for dementia with Lewy bodies (DLB) include occipital hypoperfusion and decreased cardiac uptake of ¹²³I-metaiodobenzylguanidine (MIBG). In this study, we performed both brain perfusion single photon emission computed tomography (SPECT) and MIBG myocardial scintigraphy in the same subjects and evaluated their sensitivity to detect the characteristic features of DLB. Methods: Twenty-five patients with probable DLB (76.8 ± 5.1 years old, 10 male) underwent ^99mTc-ethylcysteinate dimer brain perfusion SPECT and ¹²³I-MIBG myocardial scintigraphy. The results of SPECT were analyzed using a qualitative analysis program, easy Z score imaging system (eZIS), and an automated quantitative analysis program, 3DSRT. Results: Qualitative analysis using eZIS demonstrated occipital hypoperfusion in 17 subjects (68%). The quantified mean blood perfusion in the occipital segment on the 3DSRT template was 40.7 ± 5.03 ml/100 g/min (right) and 40.5 ± 5.38 ml/100 g/min (left), and in 19 DLB patients these values were below the normal limit. Twenty-four of 25 subjects (96%) had decreased cardiac MIBG uptake in the delayed image. Conclusion: MIBG myocardial scintigraphy was superior to brain perfusion SPECT in detecting a characteristic feature of DLB. Our results suggest that combining SPECT and MIBG scintigraphy could increase the accuracy of clinical diagnosis of DLB.

“…The difference in the mean VR-II score between 2y-MCI-C and 2y-MCI-NC (Z scores generated from normal control data) was 2.28, which was higher than that in the mean LM-II score (0.68; table 3). Additionally, unilateral or bilateral hypoperfusion of the precuneus area in SPECT analyzed by statistical methods, 3-dimensional stereotactic surface projection [19] or the easy Z score Imaging System [20], was significantly different between the MCI-C and the MCI-NC groups (online suppl. table 1; for all online suppl.…”

Section: Resultsmentioning

confidence: 99%

Visual Reproduction on the Wechsler Memory Scale-Revised as a Predictor of Alzheimer’s Disease in Japanese Patients with Mild Cognitive Impairments

Hori¹,

Sanjo²,

Tomita

et al. 2013

Background: The Visual Reproduction (VR) test is used to assess mild cognitive impairment (MCI), but the characteristics of visual memory in Japanese MCI patients remain unclear. Methods: VR scores of 27 MCI patients were evaluated using the Wechsler Memory Scale-Revised. Scores of MCI, no-dementia, and Alzheimer’s disease (AD) groups were then compared. Results: The annual conversion rate of MCI to AD was 18.8%. Mean VR-I and VR-II baseline scores for MCI patients were 33.3 ± 5.6 and 20.5 ± 14.0, respectively. Mean VR-II scores for converted and nonconverted MCI patients were 7.2 ± 8.7 and 29.8 ± 9.3, respectively. Conclusions: It is likely that VR-II and VR-II/I scores are more sensitive for predicting conversion to AD in Japanese than in American MCI patients. Our results indicate that VR is a sensitive and useful measure for predicting the conversion of Japanese MCI patients to AD within 2 years.