An easy way for the hydrolysis, pre-concentration, and chemical stabilization of crocetin from saffron powder

Fiorito, Serena; Palumbo, Lucia; Epifano, Francesco; Collevecchio, Chiara; Cardellini, Fabio; Bastianini, Maria; Spogli, Roberto; Genovese, Salvatore

doi:10.1016/j.foodchem.2022.132040

Cited by 11 publications

(6 citation statements)

References 26 publications

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“…37 LDHs are ideally biocompatible and have several industrial applications to produce a plethora of cosmetic, nutraceutical, and pharmaceutical preparations. 38 During the last three years, lamellar solids have found extensive use in phytochemistry and have been shown to be tremendously efficient for the selective extraction of classes of plant secondary metabolites like flavonoids, catechins, alkaloids, 39 diarylheptanoids, 40 bitter secoiridoids, 41,42 capsaicinoids, 43 oxyprenylated coumarins, 44 tetraterpenes, 45 and anthocyans. 46 48 The pattern of adsorption was practically the same, allowing good to excellent recovery of anthraquinones (all or some) by using the same two sorbents mentioned above in addition to magnesium aluminum azelate, which also displayed good performance.…”

Section: Lamellar Solidsmentioning

confidence: 99%

Solid‐phase adsorption methodologies of naturally occurring anthraquinones: A review

Palumbo

Fiorito

Epifano

et al. 2023

Phytochemical Analysis

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Introduction: Solid-phase extraction applied to plant matrices is nowadays a wellvalidated technique allowing to concentrate and purify different secondary metabolites. Several classes of phytochemicals have been selectively extracted by this methodology. During the last decade attention has been focused on biologically active anthraquinones from numerous sources like edible, healthy, and medicinal plants. Objectives: The aim of this review is to provide a detailed literature survey of the solid-phase adsorption methodologies for the extraction of natural anthraquinones reported so far and to discuss and propose future directions in this field of research. Materials and Methods: Substructure search was performed in the SciFinder Scholar, PubMed, Medline, and Scopus databases. Results: The first report about application of solid-phase adsorption for the purification of anthraquinones appeared in the literature in 2002. From this date, and in particular during recent years, the most notable examples included the use of chitin-and chitosan-based polymers, of molecularly imprinted polymers, of coated magnetic nanoparticles, of miniaturized matrix solid-phase dispersion, of functionalized resins, of differently structured lamellar solids, and finally of vortex-synchronized matrix solid-phase dispersion. Conclusions:The herein detailed solid-phase adsorption methodologies are powerful tools to selectively extract natural anthraquinones and/or provide anthraquinoneenriched phytopreparations. Nevertheless, many other important methods have been applied to synthetic anthraquinones (e.g., azo dyes). These could be conveniently employed also for natural anthranoids. Studies in this field are discussed in this review article.

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Section: Lamellar Solidsmentioning

confidence: 99%

Solid‐phase adsorption methodologies of naturally occurring anthraquinones: A review

Palumbo

Fiorito

Epifano

et al. 2023

Phytochemical Analysis

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“…In recent years, detection techniques of saffron have commonly included chromatography, spectroscopy, mass spectrometry and electronic nose 9 . Chromatographic methods involve gas chromatography, high‐performance liquid chromatography and thin‐layer chromatography 4,8,10‐13 . Spectrometric techniques include ultraviolet–visible, near‐infrared, infrared and fluorescence spectrometry 14‐17 .…”

Section: Introductionmentioning

confidence: 99%

“…9 Chromatographic methods involve gas chromatography, high-performance liquid chromatography and thin-layer chromatography. 4,8,[10][11][12][13] Spectrometric techniques include ultraviolet-visible, near-infrared, infrared and fluorescence spectrometry. [14][15][16][17] Mass spectrometry is often used in conjunction with other instruments and mainly involve high-resolution mass spectrometry, electrospray ionization-mass spectrometry and ultraperformance liquid chromatography-mass spectrometry.…”

Section: Introductionmentioning

confidence: 99%

Rapid detection and quantification of adulteration in saffron by excitation–emission matrix fluorescence combined with multi‐way chemometrics

Chen,

Wu,

Wang

et al. 2023

J Sci Food Agric

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BackgroundSaffron has gained people's attention and love for its unique flavor and valuable edible value, but the problem of saffron adulteration in the market is also serious. It is urgent for us to find a simple and rapid identification and quantitative estimation of adulteration in saffron. Therefore, the excitation‐emission matrix fluorescence combined with multi‐way chemometrics was proposed for the detection and quantification of adulteration in saffron.ResultsThe fluorescence composition analysis of saffron and saffron adulterants (safflower, marigold and madder) were accomplished by alternating trilinear decomposition algorithm (ATLD). The ATLD and two‐dimensional principal component analysis combined with k nearest neighbor (ATLD‐kNN and 2DPCA‐kNN) and ATLD combined with data driven soft independent modeling of class analogies (ATLD‐DD‐SIMCA) were applied for rapid detection of adulteration in saffron. 2DPCA‐kNN and ATLD‐DD‐SIMCA methods were adopted for the classification of chemical EEM data firstly with 100% correct classification rate. The content of adulteration of adulterated saffron was predicted by the N‐way partial least squares regression (N‐PLS) algorithm. In addition, new samples were correctly classified and the adulteration level in adulterated saffron was estimated semi‐quantitatively, which verifies the reliability of these models.ConclusionATLD‐DD‐SIMCA and 2DPCA‐kNN are recommended methods for the classification of pure saffron and adulterated saffron. N‐PLS algorithm shows potential in prediction of adulteration levels. These methods are expected to solve more complex problems in food authenticity.This article is protected by copyright. All rights reserved.

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“…Crocetin is an aglycone of crocin naturally occurring in saffron and is produced in biological systems by hydrolysis of crocins as a bioactive metabolite [4]. Crocins and crocetin have major differences in terms of their nutritional, nutraceutical, and pharmacological benefits, which are attributed to their different chemical structures [5]. The development of amyloid fibrils, which are connected to Alzheimer's disease, may also be suppressed by crocetin, and it significantly enhances cell cycle arrest via p53‐independent mechanisms followed by P21 activation [6].…”

Section: Introductionmentioning

confidence: 99%

A countercurrent chromatography solvent system based on deep eutectic solvents for separation of cis‐ and trans‐crocetin from Gardenia jasminoides Ellis

Wen,

Shen,

Cao

et al. 2023

J of Separation Science

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Due to the structural similarity and large difference in concentration, the separation of trans‐ and cis‐crocetin has been challenging, and the cis‐crocetin is usually neglected. In this work, a countercurrent chromatography method was developed for the quick separation of trans‐crocetin and cis‐crocetin from the hydrolytic extract of Gardenia jasminoides Ellis. High purity of trans‐crocetin (>95%) and cis‐crocetin (>91%) were prepared simultaneously for the first time through a novel biphasic system based on deep eutectic solvents, n‐heptane/n‐butyl alcohol/13 mmol/L Na2CO3 in water/acetamide‐benzyltrimethylammonium chloride (4:1, mol/mol) (4:7:9:1, v/v). The addition of deep eutectic solvent significantly improved the separation efficiency. The two targets can be easily recovered from the separation system through simple acidification and precipitation. It has potential for preparative separations on a large scale.

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An easy way for the hydrolysis, pre-concentration, and chemical stabilization of crocetin from saffron powder

Cited by 11 publications

References 26 publications

Solid‐phase adsorption methodologies of naturally occurring anthraquinones: A review

Solid‐phase adsorption methodologies of naturally occurring anthraquinones: A review

Rapid detection and quantification of adulteration in saffron by excitation–emission matrix fluorescence combined with multi‐way chemometrics

A countercurrent chromatography solvent system based on deep eutectic solvents for separation of cis‐ and trans‐crocetin from Gardenia jasminoides Ellis

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