An Easy Access to Construct Some Fused 1,2,4‐Triazines with Ring Junction Nitrogen Systems and Their Biological Evaluation

Abstract

The chemical reactivity of 4‐amino‐6‐benzyl‐3‐mercapto‐1,2,4‐triazine‐5(4H)‐one (1) towards various aliphatic or/and mono and bis aromatic carboxylic acid derivatives to give the corresponding fused heterocyclic systems, 1,3,4‐thiadiazoles 4, 5, 6, which incorporating 1,2,4‐triazine nucleus was achieved. Moreover, compound 1 was subjected to react either with halo acetic acids or bromo ester to afford the respective fused nitrogen ring junction systems, thiadiazole 2 and 3, or thiadiazine 7. However, the tetracyclic ring system 9 was furnished through condensation reaction of isatine with triazine 1. In addition, some of the new synthesized compounds were evaluated as an antioxidant and antitumor agents.

Synthesis and Biological Evaluation of New Multifunctional Oxazolone Scaffolds Incorporating Phenyl Benzoate Moiety

“…The antioxidant screening of the investigated compounds was determined in vitro using the technique prescribed in literature . The inhibition for each derivative was calculated using the following mathematical equation.…”

Pharmacological Studies on Novel Triazino Quinolines

“…Various 1,2,4-triazines with different substituents display various biological properties [36]. Various substituted 1,2,4-triazinone derivatives have great importance as biological agents in medicinal and agricultural fields [37][38][39][40][41][42][43][44]. This initiated constructing compounds containing both the quinoline and triazine ring systems in the same matrix to serve as a new scaffold for the synthesis of anti-inflammatory-antimicrobial agents.…”

Synthetic Approach to Some New Annulated 1,2,4‐Triazine Skeletons with Antimicrobial and Cytotoxic Activities

“…In recent years, triazine‐containing compounds have become potential targets for bioactive compounds discovery . The 1,2,4‐triazine skeleton is frequently used as a pharmacophore for the modification of known pharmaceuticals .…”

“…In recent years, triazine‐containing compounds have become potential targets for bioactive compounds discovery . The 1,2,4‐triazine skeleton is frequently used as a pharmacophore for the modification of known pharmaceuticals . Various substituted 1,2,4‐triazinone derivatives have a great importance as biological agents in medicinal and agricultural fields .…”

“…The 1,2,4‐triazine skeleton is frequently used as a pharmacophore for the modification of known pharmaceuticals . Various substituted 1,2,4‐triazinone derivatives have a great importance as biological agents in medicinal and agricultural fields . Furthermore, significant activities have been focused towards this specific substances, particularly, 4‐amino‐1,2,4‐triazin‐5‐one derivatives that have predominate interest because of the herbicidal , antimicrobial , anti‐HIV , and anticancer activities .…”