Abstract:A novel NIR absorbing aza-BODIPY photosensitizer with high 1O2 quantum yield and excellent photothermal conversion efficiency was designed for synergistic phototherapy.
“…Unlike other optical imaging techniques, PTI does not require any fluorescent tags and thus can be ascribed as non‐labeling technique. It is often applied in conjunction with photothermal therapy (PTT) and photodynamic therapy (PDT) . Under NIR irradiation, photosensitizers can generate high singlet oxygen quantum yield, showing photothermal conversion efficiency and outstanding photoacoustic response–guided simultaneous PDT and PTT.…”
Section: Pharmacological Nanoparticles From Emulsion Techniquesmentioning
Nanoparticles have the advantages over micron‐sized particles to typically provide higher intracellular uptake and drug bioavailability. Emulsion techniques are commonly used methods for producing nanoparticles aiming at high encapsulation efficiency, high stability, and low toxicity. Here, the recent developments of nanoparticles prepared from emulsions, the synthesis of nanoparticles, their physicochemical properties, and their biomedical applications are discussed. Selection of techniques, such as emulsion polymerization, miniemulsion polymerization, microemulsion polymerization, and emulsion‐solvent evaporation processes, strongly influences morphologies, size distributions, and particle properties. Details in the synthetic strategies governing the performance of nanoparticles in bioimaging, biosensing, and drug delivery are presented. Benefits and limitations of molecular imaging techniques are also discussed.
“…Unlike other optical imaging techniques, PTI does not require any fluorescent tags and thus can be ascribed as non‐labeling technique. It is often applied in conjunction with photothermal therapy (PTT) and photodynamic therapy (PDT) . Under NIR irradiation, photosensitizers can generate high singlet oxygen quantum yield, showing photothermal conversion efficiency and outstanding photoacoustic response–guided simultaneous PDT and PTT.…”
Section: Pharmacological Nanoparticles From Emulsion Techniquesmentioning
Nanoparticles have the advantages over micron‐sized particles to typically provide higher intracellular uptake and drug bioavailability. Emulsion techniques are commonly used methods for producing nanoparticles aiming at high encapsulation efficiency, high stability, and low toxicity. Here, the recent developments of nanoparticles prepared from emulsions, the synthesis of nanoparticles, their physicochemical properties, and their biomedical applications are discussed. Selection of techniques, such as emulsion polymerization, miniemulsion polymerization, microemulsion polymerization, and emulsion‐solvent evaporation processes, strongly influences morphologies, size distributions, and particle properties. Details in the synthetic strategies governing the performance of nanoparticles in bioimaging, biosensing, and drug delivery are presented. Benefits and limitations of molecular imaging techniques are also discussed.
“…C‐4 is mainly composed of four parts (Figure a), including the aza‐BODIPY core, thienyl rings, bromine atoms, and flexible alkyl chains. Thienyl rings with low steric bulk, as the electron‐rich donors, were conjugated at positions 3 and 5 of the electron‐deficient aza‐BODIPY core to form a donor–acceptor (D–A) architecture with a small Δ E ST value and enhanced NIR absorption, as well as an enhanced ISC process by increasing ⟨ 1 Ψ | Ĥ SO | 3 Ψ ⟩ . Bromine atoms were included to further enhance ISC and nonradiative transition processes .…”
The development of efficient phototherapeutic agents (PTA) through rational and specific principles exhibits great potential to the biomedical field. In this study, a facile and rational strategy was used to design PTA through perturbation theory. According to the theory, both the intersystem crossing rate for singlet oxygen generation and nonradiative transition for photothermal conversion efficiency can be simultaneously enhanced by the rational optimization of donor–acceptor groups, heavy atom number, and their functional positions, which can effectively decrease the energy gap between the singlet and triplet states and increase the spin‐orbit coupling constant. Finally, efficient PTA were obtained that showed excellent performance in multimode‐imaging‐guided synergetic photodynamic/photothermal therapy. This study therefore expands the intrinsic mechanism of organic PTA and should help guide the rational design of future organic PTA via perturbation theory.
“…Another BODIPY PS was synthesized by Tang et al for combined PDT and PTT ( Figure ) . Both iodine‐ and bromine substituents were introduced to the BODIPY skeleton to increase the 1 O 2 generation quantum yield.…”
Section: Bodipy Nano‐photosensitizers For Combined Pdt and Pttmentioning
confidence: 99%
“…c) Schematic illustration of PAI and photothermal imaging (PTI) ‐guided PTT/PDT synergistic phototherapy with xenon lamp irradiation, using IABDP NPs. All panels reproduced with permission . Copyright 2017, The Royal Society of Chemistry.…”
Section: Bodipy Nano‐photosensitizers For Combined Pdt and Pttmentioning
As traditional phototherapy agents, boron dipyrromethene (BODIPY) photosensitizers have attracted increasing attention due to their high molar extinction coefficients, high phototherapy efficacy, and excellent photostability. After being formed into nanostructures, BODIPY‐containing nano‐photosensitizers show enhanced water solubility and biocompatibility as well as efficient tumor accumulation compared to BODIPY molecules. Hence, BODIPY nano‐photosensitizers demonstrate a promising potential for fighting cancer. This review contains three sections, classifying photodynamic therapy (PDT), photothermal therapy (PTT), and the combination of PDT and PTT based on BODIPY nano‐photosensitizers. It summarizes various BODIPY nano‐photosensitizers, which are prepared via different approaches including molecular precipitation, supramolecular interactions, and polymer encapsulation. In each section, the design strategies and working principles of these BODIPY nano‐photosensitizers are highlighted. In addition, the detailed in vitro and in vivo applications of these recently developed nano‐photosensitizers are discussed together with future challenges in this field, highlighting the potential of these promising nanoagents for new tumor phototherapies.
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